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Comparison of the blood, bone marrow, and cerebrospinal fluid metabolomes in children with b-cell acute lymphoblastic leukemia.
Schraw, Jeremy M; Woodhouse, J P; Bernhardt, Melanie B; Taylor, Olga A; Horton, Terzah M; Scheurer, Michael E; Okcu, M Fatih; Rabin, Karen R; Lupo, Philip J; Brown, Austin L.
Afiliación
  • Schraw JM; Section of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. jeremy.schraw@bcm.edu.
  • Woodhouse JP; Center for Epidemiology and Population Health, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. jeremy.schraw@bcm.edu.
  • Bernhardt MB; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Houston, TX, USA. jeremy.schraw@bcm.edu.
  • Taylor OA; Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA. jeremy.schraw@bcm.edu.
  • Horton TM; Section of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza MS: BCM622, Houston, TX, 77030, USA. jeremy.schraw@bcm.edu.
  • Scheurer ME; Section of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
  • Okcu MF; Center for Epidemiology and Population Health, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
  • Rabin KR; Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Houston, TX, USA.
  • Lupo PJ; Section of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
  • Brown AL; Center for Epidemiology and Population Health, Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA.
Sci Rep ; 11(1): 19613, 2021 10 04.
Article en En | MEDLINE | ID: mdl-34608220
Metabolomics may shed light on treatment response in childhood acute lymphoblastic leukemia (ALL), however, most assessments have analyzed bone marrow or cerebrospinal fluid (CSF), which are not collected during all phases of therapy. Blood is collected frequently and with fewer risks, but it is unclear whether findings from marrow or CSF biomarker studies may translate. We profiled end-induction plasma, marrow, and CSF from N = 10 children with B-ALL using liquid chromatography-mass spectrometry. We estimated correlations between plasma and marrow/CSF metabolite abundances detected in ≥ 3 patients using Spearman rank correlation coefficients (rs). Most marrow metabolites were detected in plasma (N = 661; 81%), and we observed moderate-to-strong correlations (median rs 0.62, interquartile range [IQR] 0.29-0.83). We detected 328 CSF metabolites in plasma (90%); plasma-CSF correlations were weaker (median rs 0.37, IQR 0.07-0.70). We observed plasma-marrow correlations for metabolites in pathways associated with end-induction residual disease (pyruvate, asparagine) and plasma-CSF correlations for a biomarker of fatigue (gamma-glutamylglutamine). There is considerable overlap between the plasma, marrow, and CSF metabolomes, and we observed strong correlations for biomarkers of clinically relevant phenotypes. Plasma may be suitable for biomarker studies in B-ALL.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Médula Ósea / Biomarcadores / Leucemia-Linfoma Linfoblástico de Células Precursoras B / Metaboloma / Metabolómica Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Médula Ósea / Biomarcadores / Leucemia-Linfoma Linfoblástico de Células Precursoras B / Metaboloma / Metabolómica Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido