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Participation, retention and uptake in a multicentre pre-exposure prophylaxis cohort using online, smartphone-compatible data collection.
Hovaguimian, F; Martin, E; Reinacher, M; Rasi, M; Schmidt, A J; Bernasconi, E; Boffi El Amari, E; Braun, D L; Calmy, A; Darling, K; Christinet, V; Depmeier, C; Hauser, C; Läuchli, S; Notter, J; Stoeckle, M; Surial, B; Vernazza, P; Bruggmann, P; Tarr, P; Haerry, D; Bize, R; Low, N; Lehner, A; Böni, J; Kouyos, R D; Fehr, J S; Hampel, B.
Afiliación
  • Hovaguimian F; Department of Public and Global Health, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
  • Martin E; Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, Zurich, Switzerland.
  • Reinacher M; Department of Public and Global Health, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
  • Rasi M; Department of Public and Global Health, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
  • Schmidt AJ; Department of Public and Global Health, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.
  • Bernasconi E; Division of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.
  • Boffi El Amari E; Sigma Research, London School of Hygiene and Tropical Medicine, London, UK.
  • Braun DL; Division of Infectious Diseases, Regional Hospital Lugano, Lugano, Switzerland.
  • Calmy A; Infectious Diseases and Internal Medicine Private Practice, Geneva, Switzerland.
  • Darling K; Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, Zurich, Switzerland.
  • Christinet V; Laboratory of Virology and Division of Infectious Diseases, Geneva University Hospital, Geneva, Switzerland.
  • Depmeier C; Infectious Diseases Service, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
  • Hauser C; Checkpoint Vaud, Lausanne, Switzerland.
  • Läuchli S; Private practice Kalkbreite, Zurich, Switzerland.
  • Notter J; Department of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland.
  • Stoeckle M; Dermatologic Centre Zurich, Zurich, Switzerland.
  • Surial B; Division of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.
  • Vernazza P; Department of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University of Basel, Basel, Switzerland.
  • Bruggmann P; Department of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland.
  • Tarr P; Division of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.
  • Haerry D; Arud Centre for Addiction Medicine, Zurich, Switzerland.
  • Bize R; Kantonsspital Baselland, University of Basel, Basel, Switzerland.
  • Low N; Positive Council, Zurich, Switzerland.
  • Lehner A; Department of Epidemiology and Health Systems, Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.
  • Böni J; Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
  • Kouyos RD; Swiss AIDS Federation, Zurich, Switzerland.
  • Fehr JS; Institute of Medical Virology, University of Zurich, Zurich, Switzerland.
  • Hampel B; Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, Zurich, Switzerland.
HIV Med ; 23(2): 146-158, 2022 02.
Article en En | MEDLINE | ID: mdl-34605153
OBJECTIVES: The aim of the study was to assess the feasibility of a national pre-exposure prophylaxis (PrEP) programme using smartphone-compatible data collection. METHODS: This was a multicentre cohort study (NCT03893188) enrolling individuals interested in PrEP in Switzerland. All centres participate in the SwissPrEPared programme, which uses smartphone-compatible data collection. Feasibility was assessed after centres had enrolled at least one participant. Participants were HIV-negative individuals presenting for PrEP counselling. Outcomes were participation (number enrolled/number eligible), enrolment rates (number enrolled per month), retention at first follow-up (number with first follow-up/number enrolled), and uptake (proportion attending first visit as scheduled). Participant characteristics were compared between those retained after baseline assessment and those who dropped out. RESULTS: Between April 2019 and January 2020, 987 individuals were assessed for eligibility, of whom 969 were enrolled (participation: 98.2%). The median enrolment rate was 86 per month [interquartile range (IQR) 52-137]. Retention at first follow-up and uptake were both 80.7% (782/969 and 532/659, respectively). At enrolment, the median age was 40 (IQR 33-47) years, 95% were men who have sex with men, 47% had a university degree, and 75.5% were already taking PrEP. Most reported multiple casual partners (89.2%), previous sexually transmitted infections (74%) and sexualized drug use (73.1%). At baseline, 25.5% tested positive for either syphilis, gonorrhoea or chlamydia. Participants who dropped out were at lower risk of HIV infection than those retained after baseline assessment. CONCLUSIONS: In a national PrEP programme using smartphone-compatible data collection, participation, retention and uptake were high. Participants retained after baseline assessment were at considerable risk of HIV infection. Younger, less educated individuals were underrepresented in the SwissPrEPared cohort.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Fármacos Anti-VIH / Profilaxis Pre-Exposición / Minorías Sexuales y de Género Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Humans / Male Idioma: En Revista: HIV Med Asunto de la revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Año: 2022 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / Fármacos Anti-VIH / Profilaxis Pre-Exposición / Minorías Sexuales y de Género Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Humans / Male Idioma: En Revista: HIV Med Asunto de la revista: SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS) Año: 2022 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido