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Fragment-based lead discovery of indazole-based compounds as AXL kinase inhibitors.
Ng, Pearly Shuyi; Foo, Klement; Sim, Sandra; Wang, Gang; Huang, Chuhui; Tan, Li Hong; Poulsen, Anders; Liu, Boping; Tee, Doris Hui Ying; Ahmad, Nur Huda Binte; Wang, Sifang; Ke, Zhiyuan; Lee, May Ann; Kwek, Zekui P; Joy, Joma; Anantharajan, Jothi; Baburajendran, Nithya; Pendharkar, Vishal; Manoharan, Vithya; Vuddagiri, Susmitha; Sangthongpitag, Kanda; Hill, Jeffrey; Keller, Thomas H; Hung, Alvin W.
Afiliación
  • Ng PS; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, 138670, Singapore. Electronic address: pearly.ng.shuyi@gmail.com.
  • Foo K; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, 138670, Singapore.
  • Sim S; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, 138670, Singapore.
  • Wang G; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, 138670, Singapore.
  • Huang C; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, 138670, Singapore.
  • Tan LH; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, 138670, Singapore.
  • Poulsen A; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, 138670, Singapore.
  • Liu B; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, 138670, Singapore.
  • Tee DHY; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, 138670, Singapore.
  • Ahmad NHB; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, 138670, Singapore.
  • Wang S; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, 138670, Singapore.
  • Ke Z; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, 138670, Singapore.
  • Lee MA; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, 138670, Singapore.
  • Kwek ZP; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, 138670, Singapore.
  • Joy J; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, 138670, Singapore.
  • Anantharajan J; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, 138670, Singapore.
  • Baburajendran N; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, 138670, Singapore.
  • Pendharkar V; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, 138670, Singapore.
  • Manoharan V; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, 138670, Singapore.
  • Vuddagiri S; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, 138670, Singapore.
  • Sangthongpitag K; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, 138670, Singapore.
  • Hill J; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, 138670, Singapore.
  • Keller TH; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, 138670, Singapore.
  • Hung AW; Experimental Drug Development Centre, 10 Biopolis Road #05-01 Chromos, 138670, Singapore. Electronic address: alvin@ligaturetx.com.
Bioorg Med Chem ; 49: 116437, 2021 11 01.
Article en En | MEDLINE | ID: mdl-34600239
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Proto-Oncogénicas / Proteínas Tirosina Quinasas Receptoras / Inhibidores de Proteínas Quinasas / Descubrimiento de Drogas / Indazoles Límite: Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Proto-Oncogénicas / Proteínas Tirosina Quinasas Receptoras / Inhibidores de Proteínas Quinasas / Descubrimiento de Drogas / Indazoles Límite: Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido