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Evaluation of dopamine transporter density in healthy Brazilians using Tc-99m TRODAT-1 SPECT.
Reis, Marilia Alves Dos; Gadelha, Ary; Felício, André C; Hoexter, Marcelo Queiroz; Batista, Ilza Rosa; Braga-Neto, Pedro; Calzavara, Mariana; Cavagnolli, Daniel Alves; Higuchi, Cinthia; Leite, Melissa Furlaneto Lellis; Nogueira, Solange Amorim; Wagner, Jairo; Castiglioni, Mario Luiz Vieira; Shih, Ming Chi; Bressan, Rodrigo Affonseca.
Afiliación
  • Reis MAD; Laboratory of Integrative Neuroscience, Universidade Federal de São Paulo (LiNC- EPM/UNIFESP), São Paulo, Brazil.
  • Gadelha A; Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil.
  • Felício AC; Department of Diagnostic Imaging, Universidade Federal de São Paulo (DDI/UNIFESP), São Paulo, Brazil.
  • Hoexter MQ; Laboratory of Integrative Neuroscience, Universidade Federal de São Paulo (LiNC- EPM/UNIFESP), São Paulo, Brazil.
  • Batista IR; Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil.
  • Braga-Neto P; Schizophrenia Program of the Department of Psychiatry, Universidade Federal de São Paulo (PROESQ - EPM/UNIFESP), São Paulo, Brazil.
  • Calzavara M; Hospital Israelita Albert Einstein, São Paulo, Brazil.
  • Cavagnolli DA; Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil.
  • Higuchi C; Department of Diagnostic Imaging, Universidade Federal de São Paulo (DDI/UNIFESP), São Paulo, Brazil.
  • Leite MFL; Neurology Division, Department of Clinical Medicine, Universidade Federal do Ceará, Ceará, Brazil.
  • Nogueira SA; Center of Health Sciences, Universidade Estadual do Ceará, Ceará, Brazil.
  • Wagner J; Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil.
  • Castiglioni MLV; Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil.
  • Shih MC; Laboratory of Integrative Neuroscience, Universidade Federal de São Paulo (LiNC- EPM/UNIFESP), São Paulo, Brazil.
  • Bressan RA; Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil.
Medicine (Baltimore) ; 100(39): e27192, 2021 Oct 01.
Article en En | MEDLINE | ID: mdl-34596116
ABSTRACT: The presynaptic dopamine transporter (DAT) modulates the uptake of dopamine by regulating its concentration in the central nervous system. We aimed to evaluate the DAT binding potential (DAT-BP) in a sample of healthy Brazilians through technetium-99 metastable TRODAT-1 single-photon emission computed tomography imaging.We selected 126 healthy individuals comprising 72 men and 54 women, aged 18 to 80 years. We conducted semi-quantitative evaluation in transaxial slices, following which we identified the regions of interest in the striatal region using the occipital lobe as a region of non-specific DAT-BP.We found a decrease in DAT-BP in healthy individuals aged over 30 years, culminating in a 42% mean reduction after 80 years. There was no difference in the decrease by age group between the right (linear regression test [R2] linear = 0.466) and left striatum (R2 linear = 0.510). Women presented a higher DAT-BP than men (women: R2 linear = 0.431; men: R2 linear = 0.457); nonetheless, their decrease by age group was equal to that in men.Our study sheds light on important DAT-BP findings in healthy Brazilian subjects. Our results will facilitate understanding of brain illnesses that involve the dopamine system, such as neuropsychiatric disorders.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tropanos / Encéfalo / Compuestos de Organotecnecio / Tomografía Computarizada de Emisión de Fotón Único / Radiofármacos / Proteínas de Transporte de Dopamina a través de la Membrana Plasmática Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do sul / Brasil Idioma: En Revista: Medicine (Baltimore) Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tropanos / Encéfalo / Compuestos de Organotecnecio / Tomografía Computarizada de Emisión de Fotón Único / Radiofármacos / Proteínas de Transporte de Dopamina a través de la Membrana Plasmática Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do sul / Brasil Idioma: En Revista: Medicine (Baltimore) Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos