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Peripheral T-cell lymphoma: molecular profiling recognizes subclasses and identifies prognostic markers.
Rodríguez, Marta; Alonso-Alonso, Ruth; Tomás-Roca, Laura; Rodríguez-Pinilla, Socorro M; Manso-Alonso, Rebeca; Cereceda, Laura; Borregón, Jennifer; Villaescusa, Teresa; Córdoba, Raúl; Sánchez-Beato, Margarita; Fernández-Miranda, Ismael; Betancor, Isabel; Bárcena, Carmen; García, Juan F; Mollejo, Manuela; García-Cosio, Mónica; Martin-Acosta, Paloma; Climent, Fina; Caballero, Dolores; de la Fuente, Lorena; Mínguez, Pablo; Kessler, Linda; Scholz, Catherine; Gualberto, Antonio; Mondéjar, Rufino; Piris, Miguel A.
Afiliación
  • Rodríguez M; Pathology Department, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain.
  • Alonso-Alonso R; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), ISCIII, Madrid, Spain.
  • Tomás-Roca L; Pathology Department, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain.
  • Rodríguez-Pinilla SM; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), ISCIII, Madrid, Spain.
  • Manso-Alonso R; Pathology Department, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain.
  • Cereceda L; Pathology Department, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain.
  • Borregón J; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), ISCIII, Madrid, Spain.
  • Villaescusa T; Pathology Department, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain.
  • Córdoba R; Pathology Department, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain.
  • Sánchez-Beato M; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), ISCIII, Madrid, Spain.
  • Fernández-Miranda I; Pathology Department, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain.
  • Betancor I; Lymphoma Unit, Department of Hematology, Fundación Jiménez Díaz University Hospital, Health Research Institute IIS-FJD, Madrid, Spain.
  • Bárcena C; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), ISCIII, Madrid, Spain.
  • García JF; Lymphoma Unit, Department of Hematology, Fundación Jiménez Díaz University Hospital, Health Research Institute IIS-FJD, Madrid, Spain.
  • Mollejo M; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), ISCIII, Madrid, Spain.
  • García-Cosio M; Lymphoma Research Group, Medical Oncology Department, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana, Madrid, Spain.
  • Martin-Acosta P; Lymphoma Research Group, Medical Oncology Department, Instituto de Investigación Sanitaria Puerta de Hierro-Segovia de Arana, Madrid, Spain.
  • Climent F; Pathology Department, Instituto de Investigación Sanitaria Fundación Jiménez Díaz, Madrid, Spain.
  • Caballero D; Pathology Department, Hospital Universitario 12 de Octubre, Madrid, Spain.
  • de la Fuente L; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), ISCIII, Madrid, Spain.
  • Mínguez P; Pathology Department, Hospital MD Anderson Cancer Center, Madrid, Spain.
  • Kessler L; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), ISCIII, Madrid, Spain.
  • Scholz C; Pathology Department, Hospital Virgen de la Salud, Toledo, Spain.
  • Gualberto A; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), ISCIII, Madrid, Spain.
  • Mondéjar R; Pathology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain.
  • Piris MA; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), ISCIII, Madrid, Spain.
Blood Adv ; 5(24): 5588-5598, 2021 12 28.
Article en En | MEDLINE | ID: mdl-34592752
Peripheral T-cell lymphoma (PTCL) is a clinically aggressive disease, with a poor response to therapy and a low overall survival rate of approximately 30% after 5 years. We have analyzed a series of 105 cases with a diagnosis of PTCL using a customized NanoString platform (NanoString Technologies, Seattle, WA) that includes 208 genes associated with T-cell differentiation, oncogenes and tumor suppressor genes, deregulated pathways, and stromal cell subpopulations. A comparative analysis of the various histological types of PTCL (angioimmunoblastic T-cell lymphoma [AITL]; PTCL with T follicular helper [TFH] phenotype; PTCL not otherwise specified [NOS]) showed that specific sets of genes were associated with each of the diagnoses. These included TFH markers, cytotoxic markers, and genes whose expression was a surrogate for specific cellular subpopulations, including follicular dendritic cells, mast cells, and genes belonging to precise survival (NF-κB) and other pathways. Furthermore, the mutational profile was analyzed using a custom panel that targeted 62 genes in 76 cases distributed in AITL, PTCL-TFH, and PTCL-NOS. The main differences among the 3 nodal PTCL classes involved the RHOAG17V mutations (P < .0001), which were approximately twice as frequent in AITL (34.09%) as in PTCL-TFH (16.66%) cases but were not detected in PTCL-NOS. A multivariate analysis identified gene sets that allowed the series of cases to be stratified into different risk groups. This study supports and validates the current division of PTCL into these 3 categories, identifies sets of markers that can be used for a more precise diagnosis, and recognizes the expression of B-cell genes as an IPI-independent prognostic factor for AITL.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfoma de Células T Periférico / Linfadenopatía Inmunoblástica Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Blood Adv Año: 2021 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfoma de Células T Periférico / Linfadenopatía Inmunoblástica Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Blood Adv Año: 2021 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos