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A bio-compatible pyridine-pyrazole hydrazide based compartmental receptor for Al3+ sensing and its application in cell imaging.
Das, Bhriguram; Dolai, Malay; Ghosh, Avijit; Dhara, Anamika; Mahapatra, Ananya Das; Chattopadhyay, Debprasad; Mabhai, Subhabrata; Jana, Atanu; Dey, Satyajit; Misra, Ajay.
Afiliación
  • Das B; Department of Chemistry, Vidyasagar University, Midnapore, 721102, West Bengal, India. ajay@mail.vidyasagar.ac.in.
  • Dolai M; Department of Chemistry, Tamralipta Mahavidyalaya, Purba Medinipur, 721636, India. satyajitdeyoc@gmail.com.
  • Ghosh A; Department of Chemistry, Prabhat Kumar College, Contai, Purba Medinipur, 721404, West Bengal, India.
  • Dhara A; Center for Research in Nanoscience and Nanotechnology, University of Calcutta, Technology Campus, Salt Lake, Kolkata 700106, India.
  • Mahapatra AD; Department of Chemistry, Hiralal Mazumdar Memorial College for Women, Dakshineswar, North 24 Parganas, Kolkata 700035, India.
  • Chattopadhyay D; ICMR-Virus Unit, ID & BG Hospital Campus, 57 Dr Suresh C Banerjee Road, Beliaghata, Kolkata 700010, India.
  • Mabhai S; ICMR-Virus Unit, ID & BG Hospital Campus, 57 Dr Suresh C Banerjee Road, Beliaghata, Kolkata 700010, India.
  • Jana A; ICMR-National Institute of Traditional Medicine, Nehru Nagar, Belagavi 59001, Karnataka, India.
  • Dey S; Department of Chemistry, Mahishadal Raj College, Purba Medinipur, 721628, India.
  • Misra A; Division of Physics and Semiconductor Science, Dongguk University, Seoul, 04620, South Korea. atanujanaic@gmail.com.
Anal Methods ; 13(37): 4266-4279, 2021 09 30.
Article en En | MEDLINE | ID: mdl-34591947
For practical applications, the development of bio-compatible organic molecules as p-block ion chemosensors is critical. Herein, we report the single crystal (SC) of new pyridine-pyrazole derived Al3+ sensor H2PPC [(Z)-N'-(2,3-dihydroxybenzylidene)-5-methyl-1-(pyridin-2-yl)-1H-pyrazole-3-carbohydrazide] as well as its Cu-complex SC. The probe exhibits an "off-on" fluorescence response towards Al3+ ions, and this has been modulated with different solvents. For selective detection of Al3+ ions, a special coordination pocket in the structural backbone is advantageous. The chemosensor exhibits a submicromolar detection level (LOD = 4.78 µM) for Al3+. The density functional theory (DFT) and time-dependent DFT (TD-DFT) calculations of H2PPC and [Al(HPP)2]+ (1) reveal that a change of the structural conformation of probe H2PPC upon complexation causes the pyrazole and pyridine units to create a specific cavity to tether Al3+, and consequently H2PPC proves to be a promising molecule for Al3+ detection. Furthermore, the probe has been successfully used to evaluate Al3+ as a low-cost kit using filter paper strips, and the in situ Al3+ ion imaging in Vero cells as well as A549 cell lines shows the sensor's nuclear envelope penetrability, indicating that it has great potential for biological and environmental applications.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazoles / Colorantes Fluorescentes Límite: Animals Idioma: En Revista: Anal Methods Año: 2021 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirazoles / Colorantes Fluorescentes Límite: Animals Idioma: En Revista: Anal Methods Año: 2021 Tipo del documento: Article País de afiliación: India Pais de publicación: Reino Unido