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Histologic Changes in Non-Small Cell Lung Cancer under Various Treatments: A Comparison of Histology and Mutation Status in Serial Samples.
Woo, Chang Gok; Son, Seung-Myoung; Lee, Ho-Chang; Han, Hye Sook; Lee, Ki Hyeong; Kim, Dohun; Kim, Eung-Gook; Lee, Ok-Jun.
Afiliación
  • Woo CG; Department of Pathology, Chungbuk National University Hospital, Cheongju, Korea.
  • Son SM; Department of Pathology, Chungbuk National University College of Medicine, Cheongju, Korea.
  • Lee HC; Department of Pathology, Chungbuk National University Hospital, Cheongju, Korea.
  • Han HS; Department of Pathology, Chungbuk National University College of Medicine, Cheongju, Korea.
  • Lee KH; Department of Pathology, Chungbuk National University Hospital, Cheongju, Korea.
  • Kim D; Department of Pathology, Chungbuk National University College of Medicine, Cheongju, Korea.
  • Kim EG; Division of Hematology-Oncology, Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea.
  • Lee OJ; Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea.
Cancer Res Treat ; 54(3): 737-743, 2022 Jul.
Article en En | MEDLINE | ID: mdl-34583457
PURPOSE: Histologic change is a resistant mechanism in lung cancer. The most common histological change is the switch from adenocarcinoma (AdenoCa) to small cell carcinoma (SCC) against to tyrosine kinase inhibitors (TKI). However, it is not clear whether other treatment modalities are involved in the histologic changes. MATERIALS AND METHODS: We investigated histological changes in eight cases, after various treatments, and compared the molecular profiles between primary tumors and changed tumors using exome sequencing where tissue was available. RESULTS: Three cases of AdenoCa that were changed into SCC retained the initial mutations after TKI and/or surgical treatment. After treatment with TKI and immunotherapy, an EGFR (epidermal growth factor receptor)-mutant AdenoCa changed to squamous cell carcinoma (SqCa). SqCa in a patient treated with surgery was changed into combined AdenoCa and SqCa. These two cases showed the same genetic variations between the two distinct non-small cell carcinomas (NSCC). Three patients experienced two histologic changes, which the changed tumors returned to its original subtype or changed to a combined tumor after treatments. Four cases showed combined histology in the first or second change. CONCLUSION: The histology of NSCC can be changed to a single pattern or combined subtypes after various treatment modalities, and the phenotypic changes seem not fixed. Therefore, additional morphologic changes may occur regardless of their genetic status and types of treatments. To refine the new treatment strategy, consecutive repeated biopsies in progressive disease or recurrent tumor are necessary.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adenocarcinoma / Carcinoma de Pulmón de Células no Pequeñas / Carcinoma Pulmonar de Células Pequeñas / Neoplasias Pulmonares Límite: Humans Idioma: En Revista: Cancer Res Treat Año: 2022 Tipo del documento: Article Pais de publicación: Corea del Sur
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Adenocarcinoma / Carcinoma de Pulmón de Células no Pequeñas / Carcinoma Pulmonar de Células Pequeñas / Neoplasias Pulmonares Límite: Humans Idioma: En Revista: Cancer Res Treat Año: 2022 Tipo del documento: Article Pais de publicación: Corea del Sur