Blockade of Serotonin 5-HT<sub>6</sub> Receptor Constitutive Activity Alleviates Cognitive Deficits in a Preclinical Model of Neurofibromatosis Type 1.

Doucet, Emilie; Grychowska, Katarzyna; Zajdel, Pawel; Bockaert, Joël; Marin, Philippe; Bécamel, Carine

Blockade of Serotonin 5-HT₆ Receptor Constitutive Activity Alleviates Cognitive Deficits in a Preclinical Model of Neurofibromatosis Type 1.

Doucet, Emilie; Grychowska, Katarzyna; Zajdel, Pawel; Bockaert, Joël; Marin, Philippe; Bécamel, Carine.

Afiliación

Doucet E; Institute of Functional Genomics, University of Montpellier, CNRS, Inserm, 34094 Montpellier, France.
Grychowska K; Department of Organic Chemistry, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Kraków, Poland.
Zajdel P; Department of Organic Chemistry, Jagiellonian University Medical College, 9 Medyczna Street, 30-688 Kraków, Poland.
Bockaert J; Institute of Functional Genomics, University of Montpellier, CNRS, Inserm, 34094 Montpellier, France.
Marin P; Institute of Functional Genomics, University of Montpellier, CNRS, Inserm, 34094 Montpellier, France.
Bécamel C; Institute of Functional Genomics, University of Montpellier, CNRS, Inserm, 34094 Montpellier, France.

Int J Mol Sci ; 22(18)2021 09 21.

Article en En | MEDLINE | ID: mdl-34576341

Asunto(s)

Neurofibromatosis 1/metabolismo; Receptores de Serotonina/metabolismo; Animales; Humanos; Serotonina/metabolismo; Tiofenos/metabolismo

Palabras clave

5-HT6 receptor; cognition; constitutive activity; inverse agonist; mTOR; neurofibromatosis type 1; neutral antagonist; rapamycin

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Receptores de Serotonina / Neurofibromatosis 1 Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Suiza

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