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Differential Effects of Polyphenols on Insulin Proteolysis by the Insulin-Degrading Enzyme.
Zheng, Qiuchen; Kebede, Micheal T; Lee, Bethany; Krasinski, Claire A; Islam, Saadman; Wurfl, Liliana A; Kemeh, Merc M; Ivancic, Valerie A; Jakobsche, Charles E; Spratt, Donald E; Lazo, Noel D.
Afiliación
  • Zheng Q; Gustaf H. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA 01610, USA.
  • Kebede MT; Gustaf H. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA 01610, USA.
  • Lee B; Gustaf H. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA 01610, USA.
  • Krasinski CA; Gustaf H. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA 01610, USA.
  • Islam S; Gustaf H. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA 01610, USA.
  • Wurfl LA; Gustaf H. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA 01610, USA.
  • Kemeh MM; Gustaf H. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA 01610, USA.
  • Ivancic VA; Gustaf H. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA 01610, USA.
  • Jakobsche CE; Gustaf H. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA 01610, USA.
  • Spratt DE; Gustaf H. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA 01610, USA.
  • Lazo ND; Gustaf H. Carlson School of Chemistry and Biochemistry, Clark University, Worcester, MA 01610, USA.
Antioxidants (Basel) ; 10(9)2021 Aug 25.
Article en En | MEDLINE | ID: mdl-34572974
The insulin-degrading enzyme (IDE) possesses a strong ability to degrade insulin and Aß42 that has been linked to the neurodegeneration in Alzheimer's disease (AD). Given this, an attractive IDE-centric strategy for the development of therapeutics for AD is to boost IDE's activity for the clearance of Aß42 without offsetting insulin proteostasis. Recently, we showed that resveratrol enhances IDE's activity toward Aß42. In this work, we used a combination of chromatographic and spectroscopic techniques to investigate the effects of resveratrol on IDE's activity toward insulin. For comparison, we also studied epigallocatechin-3-gallate (EGCG). Our results show that the two polyphenols affect the IDE-dependent degradation of insulin in different ways: EGCG inhibits IDE while resveratrol has no effect. These findings suggest that polyphenols provide a path for developing therapeutic strategies that can selectively target IDE substrate specificity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Antioxidants (Basel) Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Antioxidants (Basel) Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza