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Effects of Therapy with Fibrin Glue combined with Mesenchymal Stem Cells (MSCs) on Bone Regeneration: A Systematic Review.
Ortiz, Adriana de Cássia; Fideles, Simone Ortiz Moura; Pomini, Karina Torres; Reis, Carlos Henrique Bertoni; Bueno, Cleuber Rodrigo de Souza; Pereira, Eliana de Souza Bastos Mazuqueli; Rossi, Jéssica de Oliveira; Novais, Paulo Cezar; Pilon, João Paulo Galletti; Rosa Junior, Geraldo Marco; Buchaim, Daniela Vieira; Buchaim, Rogerio Leone.
Afiliación
  • Ortiz AC; Department of Biological Sciences, Bauru School of Dentistry (FOB/USP), University of São Paulo, Bauru 17012-901, SP, Brazil.
  • Fideles SOM; Department of Biological Sciences, Bauru School of Dentistry (FOB/USP), University of São Paulo, Bauru 17012-901, SP, Brazil.
  • Pomini KT; Department of Biological Sciences, Bauru School of Dentistry (FOB/USP), University of São Paulo, Bauru 17012-901, SP, Brazil.
  • Reis CHB; Postgraduate Program in Structural and Functional Interactions in Rehabilitation, Postgraduate Department, University of Marilia (UNIMAR), Marília 17525-902, SP, Brazil.
  • Bueno CRS; Department of Biological Sciences, Bauru School of Dentistry (FOB/USP), University of São Paulo, Bauru 17012-901, SP, Brazil.
  • Pereira ESBM; Postgraduate Program in Structural and Functional Interactions in Rehabilitation, Postgraduate Department, University of Marilia (UNIMAR), Marília 17525-902, SP, Brazil.
  • Rossi JO; Department of Biological Sciences, Bauru School of Dentistry (FOB/USP), University of São Paulo, Bauru 17012-901, SP, Brazil.
  • Novais PC; Postgraduate Program in Structural and Functional Interactions in Rehabilitation, Postgraduate Department, University of Marilia (UNIMAR), Marília 17525-902, SP, Brazil.
  • Pilon JPG; Department of Biological Sciences, Bauru School of Dentistry (FOB/USP), University of São Paulo, Bauru 17012-901, SP, Brazil.
  • Rosa Junior GM; Postgraduate Program in Structural and Functional Interactions in Rehabilitation, Postgraduate Department, University of Marilia (UNIMAR), Marília 17525-902, SP, Brazil.
  • Buchaim DV; Postgraduate Program in Structural and Functional Interactions in Rehabilitation, Postgraduate Department, University of Marilia (UNIMAR), Marília 17525-902, SP, Brazil.
  • Buchaim RL; Pro-rectory of Graduate Studies and Research, Sacred Heart University Center (UNISAGRADO), Bauru 17011-160, SP, Brazil.
Cells ; 10(9)2021 09 05.
Article en En | MEDLINE | ID: mdl-34571972
Cell therapy strategies using mesenchymal stem cells (MSCs) carried in fibrin glue have shown promising results in regenerative medicine. MSCs are crucial for tissue healing because they have angiogenic, anti-apoptotic and immunomodulatory properties, in addition to the ability to differentiate into several specialized cell lines. Fibrin sealant or fibrin glue is a natural polymer involved in the coagulation process. Fibrin glue provides a temporary structure that favors angiogenesis, extracellular matrix deposition and cell-matrix interactions. Additionally, fibrin glue maintains the local and paracrine functions of MSCs, providing tissue regeneration through less invasive clinical procedures. Thus, the objective of this systematic review was to assess the potential of fibrin glue combined with MSCs in bone or cartilage regeneration. The bibliographic search was performed in the PubMed/MEDLINE, LILACS and Embase databases, using the descriptors ("fibrin sealant" OR "fibrin glue") AND "stem cells" AND "bone regeneration", considering articles published until 2021. In this case, 12 preclinical and five clinical studies were selected to compose this review, according to the eligibility criteria. In preclinical studies, fibrin glue loaded with MSCs, alone or associated with bone substitute, significantly favored bone defects regeneration compared to scaffold without cells. Similarly, fibrin glue loaded with MSCs presented considerable potential to regenerate joint cartilage injuries and multiple bone fractures, with significant improvement in clinical parameters and absence of postoperative complications. Therefore, there is clear evidence in the literature that fibrin glue loaded with MSCs, alone or combined with bone substitute, is a promising strategy for treating lesions in bone or cartilaginous tissue.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteogénesis / Regeneración Ósea / Adhesivo de Tejido de Fibrina / Condrogénesis / Trasplante de Células Madre Mesenquimatosas / Medicina Regenerativa / Andamios del Tejido / Células Madre Mesenquimatosas Tipo de estudio: Prognostic_studies / Systematic_reviews Límite: Animals / Humans Idioma: En Revista: Cells Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteogénesis / Regeneración Ósea / Adhesivo de Tejido de Fibrina / Condrogénesis / Trasplante de Células Madre Mesenquimatosas / Medicina Regenerativa / Andamios del Tejido / Células Madre Mesenquimatosas Tipo de estudio: Prognostic_studies / Systematic_reviews Límite: Animals / Humans Idioma: En Revista: Cells Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza