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Induced Pluripotent Stem Cells (iPSCs)-Roles in Regenerative Therapies, Disease Modelling and Drug Screening.
Aboul-Soud, Mourad A M; Alzahrani, Alhusain J; Mahmoud, Amer.
Afiliación
  • Aboul-Soud MAM; Chair of Medical and Molecular Genetics Research, Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia.
  • Alzahrani AJ; Department of Clinical Sciences, College of Applied Medical Sciences, University of Hafr Al Batin, Hafr Al Batin 39524, Saudi Arabia.
  • Mahmoud A; Stem Cell Unit, Department of Anatomy, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia.
Cells ; 10(9)2021 09 05.
Article en En | MEDLINE | ID: mdl-34571968
The discovery of induced pluripotent stem cells (iPSCs) has made an invaluable contribution to the field of regenerative medicine, paving way for identifying the true potential of human embryonic stem cells (ESCs). Since the controversy around ethicality of ESCs continue to be debated, iPSCs have been used to circumvent the process around destruction of the human embryo. The use of iPSCs have transformed biological research, wherein increasing number of studies are documenting nuclear reprogramming strategies to make them beneficial models for drug screening as well as disease modelling. The flexibility around the use of iPSCs include compatibility to non-invasive harvesting, and ability to source from patients with rare diseases. iPSCs have been widely used in cardiac disease modelling, studying inherited arrhythmias, neural disorders including Alzheimer's disease, liver disease, and spinal cord injury. Extensive research around identifying factors that are involved in maintaining the identity of ESCs during induction of pluripotency in somatic cells is undertaken. The focus of the current review is to detail all the clinical translation research around iPSCs and the strength of its ever-growing potential in the clinical space.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regeneración / Diferenciación Celular / Trasplante de Células Madre / Medicina Regenerativa / Proliferación Celular / Evaluación Preclínica de Medicamentos / Células Madre Pluripotentes Inducidas / Investigación Biomédica Traslacional Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Aspecto: Ethics Límite: Animals / Humans Idioma: En Revista: Cells Año: 2021 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Regeneración / Diferenciación Celular / Trasplante de Células Madre / Medicina Regenerativa / Proliferación Celular / Evaluación Preclínica de Medicamentos / Células Madre Pluripotentes Inducidas / Investigación Biomédica Traslacional Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Aspecto: Ethics Límite: Animals / Humans Idioma: En Revista: Cells Año: 2021 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Suiza