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Scalemic mixtures preparation for optimized composition of ibuprofen solid dosage forms.
Corvis, Yohann; Guiblin, Nicolas; Négrier, Philippe; Marenco, Ivan; Dembélé, Oumar; Espeau, Philippe.
Afiliación
  • Corvis Y; Université de Paris, Faculté de Santé, CNRS, Inserm, UTCBS, Chemical and Biological Technologies for Health Group (utcbs.cnrs.fr), 4 avenue de l'Observatoire, 75006 Paris, France. Electronic address: yohann.corvis@u-paris.fr.
  • Guiblin N; CentraleSupélec, Laboratoire Structures, Propriétés et Modélisation des Solides (SPMS), UMR CNRS 8580, CentraleSupélec, Université Paris Saclay, 3 Rue Joliot Curie, 91190 Gif-sur-Yvette, France.
  • Négrier P; Laboratoire Ondes et Matière d'Aquitaine (LOMA), UMR 5798, Université de Bordeaux, Talence 33400, France.
  • Marenco I; Université de Paris, Faculté de Santé, CNRS, Inserm, UTCBS, Chemical and Biological Technologies for Health Group (utcbs.cnrs.fr), 4 avenue de l'Observatoire, 75006 Paris, France.
  • Dembélé O; Université de Paris, Faculté de Santé, CNRS, Inserm, UTCBS, Chemical and Biological Technologies for Health Group (utcbs.cnrs.fr), 4 avenue de l'Observatoire, 75006 Paris, France.
  • Espeau P; Université de Paris, Faculté de Santé, CNRS, Inserm, UTCBS, Chemical and Biological Technologies for Health Group (utcbs.cnrs.fr), 4 avenue de l'Observatoire, 75006 Paris, France.
Eur J Pharm Biopharm ; 169: 91-96, 2021 Dec.
Article en En | MEDLINE | ID: mdl-34571192
The stable and metastable phase diagrams between the sinister and the rectus ibuprofen enantiomers were established by means of thermal analysis and X-ray powder diffraction experiments as a function of temperature. The results obtained allow proving for the first time the existence, for the stable system, of a solid solution by mixing the racemic ibuprofen with one of its enantiomers for low concentration of the enantiomer. Since the rectus ibuprofen is a non-active pharmaceutical agent which can be partially bio-converted into the sinister enantiomer, the present work offers a new approach for scalemic mixtures preparation in order to improve the benefit/risk ratio related to ibuprofen solid dosage form administration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ibuprofeno / Composición de Medicamentos Límite: Humans Idioma: En Revista: Eur J Pharm Biopharm Asunto de la revista: FARMACIA / FARMACOLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Imprimir
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ibuprofeno / Composición de Medicamentos Límite: Humans Idioma: En Revista: Eur J Pharm Biopharm Asunto de la revista: FARMACIA / FARMACOLOGIA Año: 2021 Tipo del documento: Article Pais de publicación: Países Bajos