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Antibacterial and cytotoxic activities of undescribed cassiaric acid and other constituents from Cassia arereh stem barks.
Missi, Marius Balemaken; Evina, Jean Noel; Zintchem, Auguste Abouem A; October, Natasha; Bona, Angela; Moela, Pontsho; Betote Diboué, Patrick Hervé; Ngono Bikobo, Dominique Serge; Pegnyemb, Dieudonné Emmanuel.
Afiliación
  • Missi MB; Faculty of Science, Department of Organic Chemistry, University of Yaoundé 1, Yaoundé, Cameroon.
  • Evina JN; Department of Chemistry, University of Pretoria, Hatfield, South Africa.
  • Zintchem AAA; Faculty of Science, Department of Organic Chemistry, University of Yaoundé 1, Yaoundé, Cameroon.
  • October N; Faculty of Science, Department of Organic Chemistry, University of Yaoundé 1, Yaoundé, Cameroon.
  • Bona A; Department of Chemistry, Higher Teacher's Training College, University of Yaoundé 1, Yaoundé, Cameroon.
  • Moela P; Department of Chemistry, University of Pretoria, Hatfield, South Africa.
  • Betote Diboué PH; Department of Chemistry, University of Pretoria, Hatfield, South Africa.
  • Ngono Bikobo DS; Department of Biochemistry, Genetics, and Microbiology, University of Pretoria, Hatfield, South Africa.
  • Pegnyemb DE; Faculty of Science, Department of Microbiology, University of Yaoundé I, Yaoundé, Cameroon.
Nat Prod Res ; 36(17): 4330-4339, 2022 Sep.
Article en En | MEDLINE | ID: mdl-34570641
A new lupane-type triterpene, 2α,3ß-dihydroxylupan-29-oic acid (1), and one new ceramide derivative: (2S*,2'R*,3S*,4R*,5R*,7'E,11E,12'E,20E)-N-[2'-hydroxyoctadeca-6,11-dienoyl]-2-aminohexacosa-11,20-diene-1,3,4,5-tetrol (2) were isolated from the ethyl acetate fraction obtained from the methanol extract of the stem barks of Cassia arereh together with seven known compounds. Their structures were characterized using two-dimensional NMR, mass spectrometry, and compared with reported data. To date, this is the first report of the isolation of a multiple double bonds sphingolipid type (2) from this genus. The ethyl acetate extract and selected isolates were examined for antimicrobial and cytotoxic activities in vitro. Betulinaldehyde (5) has shown to be active against all bacterial strains whereas, cassiaric acid (1) and betulinic acid (6) have demonstrated to be moderately active. In addition, cassiaric acid (1) showed the best cytotoxic result against HeLa and MCF-7 cell lines tested with IC50 75.00 µM, while lupeol (3) and betulinic acid (6) displayed weak cytotoxicity at 100.00 µM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cassia / Antiinfecciosos Idioma: En Revista: Nat Prod Res Año: 2022 Tipo del documento: Article País de afiliación: Camerún Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cassia / Antiinfecciosos Idioma: En Revista: Nat Prod Res Año: 2022 Tipo del documento: Article País de afiliación: Camerún Pais de publicación: Reino Unido