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Validation of a non-motor fluctuations questionnaire in Parkinson's disease.
Faggianelli, F; Loundou, A; Baumstarck, K; Nathalie, S; Auquier, P; Eusebio, A; Defebvre, L; Brefel-Courbon, C; Houeto, J-L; Maltete, D; Tranchant, C; Derkinderen, P; Geny, C; Krystkowiak, P; Jean-Philippe, B; Macia, F; Durif, F; Poujois, A; Borg, M; Azulay, J-P; Witjas, T.
Afiliación
  • Faggianelli F; Service de Neurologie et Pathologies du Mouvement, CHU Timone, APHM, Marseille, France. Electronic address: florent.faggianelli@ap-hm.fr.
  • Loundou A; Centre D'Etudes et de Recherches sur les Services de Santé et Qualité, Faculté de Médecine, Aix-Marseille Université, Marseille, France. Electronic address: Anderson.Loundou@univ-amu.fr.
  • Baumstarck K; Centre D'Etudes et de Recherches sur les Services de Santé et Qualité, Faculté de Médecine, Aix-Marseille Université, Marseille, France. Electronic address: karine.baumstarck@univ-amu.fr.
  • Nathalie S; Service de Neurologie et Pathologies du Mouvement, CHU Timone, APHM, Marseille, France.
  • Auquier P; Centre D'Etudes et de Recherches sur les Services de Santé et Qualité, Faculté de Médecine, Aix-Marseille Université, Marseille, France. Electronic address: Pascal.Auquier@ap-hm.fr.
  • Eusebio A; Service de Neurologie et Pathologies du Mouvement, CHU Timone, APHM, Marseille, France. Electronic address: Alexandre.Eusebio@ap-hm.fr.
  • Defebvre L; Service de Neurologie A, CHRU de Lille, Hôpital Roger Salengro, Marseille, France. Electronic address: luc.defebvre@chru-lille.fr.
  • Brefel-Courbon C; Unité Neurologie cognitive, épilepsie, sommeil et mouvements anormaux, Département de Neurologie, CHU de Toulouse - Hôpital Purpan, Marseille, France. Electronic address: christine.brefel-courbon@univ-tlse3.fr.
  • Houeto JL; Service de Neurologie, CHU de Poitiers, Marseille, France. Electronic address: j.l.houeto@chu-poitiers.fr.
  • Maltete D; Unité Neurologie polyvalente, Département de neurologie, CHU de Rouen, Marseille, France. Electronic address: David.Maltete@chu-rouen.fr.
  • Tranchant C; Service de Pathologie du mouvement-Neurologie, CHU de Strasbourg, Hôpital de Hautepierre, Marseille, France. Electronic address: christine.tranchant@chru-strasbourg.fr.
  • Derkinderen P; Clinique neurologique, CHU de Nantes, Hôpital Nord Guillaume et René Laënnec, Marseille, France. Electronic address: pascal.derkinderen@chu-nantes.fr.
  • Geny C; Service de Neurologie, CHU de Montpellier, Marseille, France. Electronic address: c-geny@chu-montpellier.fr.
  • Krystkowiak P; Service de Neurologie, CHU Amiens-Picardie - Site Sud, Marseille, France. Electronic address: krystkowiak.Pierre@chu-amiens.fr.
  • Jean-Philippe B; Département de Neurologie, Hôpital Universitaire de la Pitié-Salpêtrière, APHP, Marseille, France. Electronic address: jean-philippe.brandel@aphp.fr.
  • Macia F; Service de Neurologie, Hôpital Sainte Musse, Toulon, France. Electronic address: frederic.macia@ch-toulon.fr.
  • Durif F; Service de neurologie, CHU de Clermont-Ferrand, Hôpital Gabriel Montpied, Marseille, France. Electronic address: fdurif@chu-clermontferrand.fr.
  • Poujois A; Service de Neurologie, Hôpital Fondation Rothschild, Paris, France. Electronic address: apoujois@for.paris.
  • Borg M; Service de Neurologie, CHU de Nice, Marseille, France. Electronic address: borg.m@chu-nice.fr.
  • Azulay JP; Service de Neurologie et Pathologies du Mouvement, CHU Timone, APHM, Marseille, France. Electronic address: Jean-philippe.azulay@ap-hm.fr.
  • Witjas T; Service de Neurologie et Pathologies du Mouvement, CHU Timone, APHM, Marseille, France. Electronic address: Tatiana.Witjas@ap-hm.fr.
Rev Neurol (Paris) ; 178(4): 347-354, 2022 Apr.
Article en En | MEDLINE | ID: mdl-34565624
INTRODUCTION: Non-motor fluctuations (NMF) in Parkinson's disease (PD) remain poorly recognized but have a high impact on patients' quality of life. The lack of assessment tools limits our understanding of NMF, compromising appropriate management. Our objective was to validate a hetero-questionnaire for NMF in PD patients at different stages of the disease: without treatment, without motor fluctuations, with motor fluctuations. METHODS: We included patients in 15 centers in France. Our questionnaire, NMF-Park, resulted from previous studies, allowing us to identify the more pertinent NMF for evaluation. Patients reported the presence (yes or no) of 22 selected NMF, and their link with dopaminergic medications. The assessment was repeated at one and two years to study the progression of NMF. We performed a metrological validation of our questionnaire. RESULTS: We included 255 patients (42 without treatment, 88 without motor fluctuations and 125 with motor fluctuations). After metrological validation, three dimensions of NMF were found: dysautonomic; cognitive; psychiatric. The sensory/pain dimension described in the literature was not statistically confirmed by our study. DISCUSSION: Our questionnaire was validated according to clinimetric standards, for different stages of PD. It was clinically coherent with three homogeneous dimensions. It highlighted a link between fatigue, visual accommodation disorder, and cognitive fluctuations; and the integration of sensory/pain fluctuations as part of dysautonomic fluctuations. It focused exclusively on NMF, which is interesting considering the described differences between non-motor and motor fluctuations. CONCLUSION: Our study validated a hetero-questionnaire of diagnosis for NMF for different stages of PD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Disautonomías Primarias Tipo de estudio: Guideline Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Rev Neurol (Paris) Año: 2022 Tipo del documento: Article Pais de publicación: Francia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Disautonomías Primarias Tipo de estudio: Guideline Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Rev Neurol (Paris) Año: 2022 Tipo del documento: Article Pais de publicación: Francia