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Characterization and quantification of alcohol-related polyneuropathy by magnetic resonance neurography.
Rother, Christian; Bumb, Jan Malte; Weiler, Markus; Brault, Anna; Sam, Georges; Hayes, John M; Pietsch, Adriana; Karimian-Jazi, Kianush; Jende, Johann M E; Heiland, Sabine; Kiefer, Falk; Bendszus, Martin; Kollmer, Jennifer.
Afiliación
  • Rother C; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
  • Bumb JM; Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
  • Weiler M; Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany.
  • Brault A; Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany.
  • Sam G; Department of Neurology, Heidelberg University Hospital, Heidelberg, Germany.
  • Hayes JM; Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
  • Pietsch A; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
  • Karimian-Jazi K; Department of Internal Medicine, Spital Walenstadt, Walenstadt, Switzerland.
  • Jende JME; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
  • Heiland S; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
  • Kiefer F; Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
  • Bendszus M; Division of Experimental Radiology, Department of Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany.
  • Kollmer J; Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
Eur J Neurol ; 29(2): 573-582, 2022 02.
Article en En | MEDLINE | ID: mdl-34564924
BACKGROUND: We characterized and quantified peripheral nerve damage in alcohol-dependent patients (ADP) by magnetic resonance neurography (MRN) in correlation with clinical and electrophysiologic findings. METHODS: Thirty-one adult patients with a history of excessive alcohol consumption and age-/sex-matched healthy controls were prospectively examined. After detailed neurologic and electrophysiologic testing, the patient group was subdivided into ADP with alcohol-related polyneuropathy (ALN) and without ALN (Non-ALN). 3T MRN with anatomical coverage from the proximal thigh down to the tibiotalar joint was performed using dual-echo 2-dimensional relaxometry sequences with spectral fat saturation. Detailed quantification of nerve injury by morphometric (cross-sectional area [CSA]) and microstructural MRN markers (proton spin density [ρ], apparent T2-relaxation-time [T2app ]) was conducted in all study participants. RESULTS: MRN detected nerve damage in ADP with and without ALN. A proximal-to-distal gradient was identified for nerve T2-weighted (T2w)-signal and T2app in ADP, indicating a proximal predominance of nerve lesions. While all MRN markers differentiated significantly between ADP and controls, microstructural markers were able to additionally differentiate between subgroups: tibial nerve ρ at thigh level was increased in ALN (p < 0.0001) and in Non-ALN (p = 0.0052) versus controls, and T2app was higher in ALN versus controls (p < 0.0001) and also in ALN versus Non-ALN (p = 0.0214). T2w-signal and CSA were only higher in ALN versus controls. CONCLUSIONS: MRN detects and quantifies peripheral nerve damage in ADP in vivo even in the absence of clinically overt ALN. Microstructural markers (T2app , ρ) are most suitable for differentiating between ADP with and without manifest ALN, and may help to elucidate the underlying pathomechanism in ALN.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades del Sistema Nervioso Periférico / Neuropatía Alcohólica Tipo de estudio: Prognostic_studies Límite: Adult / Humans Idioma: En Revista: Eur J Neurol Asunto de la revista: NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades del Sistema Nervioso Periférico / Neuropatía Alcohólica Tipo de estudio: Prognostic_studies Límite: Adult / Humans Idioma: En Revista: Eur J Neurol Asunto de la revista: NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido