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Anti-Obesity Effect of Hot Water Extract of Barley Sprout through the Inhibition of Adipocyte Differentiation and Growth.
Kim, Myeong-Jin; Kawk, Hye-Won; Kim, Sang-Hyeon; Lee, Hyo-Jae; Seo, Ji-Won; Kim, Jong-Tae; Jang, Seung-Hee; Kim, Min-Jeong; Kim, Young-Min.
Afiliación
  • Kim MJ; Department of Biological Science and Biotechnology, College of Life Science and Nano Technology, Hannam University, Deajoen 34054, Korea.
  • Kawk HW; Department of Biological Science and Biotechnology, College of Life Science and Nano Technology, Hannam University, Deajoen 34054, Korea.
  • Kim SH; Department of Biological Science and Biotechnology, College of Life Science and Nano Technology, Hannam University, Deajoen 34054, Korea.
  • Lee HJ; Department of Biological Science and Biotechnology, College of Life Science and Nano Technology, Hannam University, Deajoen 34054, Korea.
  • Seo JW; Department of Biological Science and Biotechnology, College of Life Science and Nano Technology, Hannam University, Deajoen 34054, Korea.
  • Kim JT; Teazen Co., Ltd., Haenam 59017, Korea.
  • Jang SH; Teazen Co., Ltd., Haenam 59017, Korea.
  • Kim MJ; Teazen Co., Ltd., Haenam 59017, Korea.
  • Kim YM; Department of Biological Science and Biotechnology, College of Life Science and Nano Technology, Hannam University, Deajoen 34054, Korea.
Metabolites ; 11(9)2021 Sep 08.
Article en En | MEDLINE | ID: mdl-34564426
Barley sprouts are known to have several effective physiological activities. In this study, the anti-obesity effect of a barley sprout hot water extract (BSE) was confirmed. Saponarin was quantitatively analyzed in BSE using HPLC, and the inhibitory effect on 3T3-L1 pre-adipocyte differentiation into adipocytes was confirmed by Oil Red O staining, TG assay, and Western blotting. In addition, the inhibitory effect of BSE on adipocyte growth was confirmed through glucose uptake and lipolysis of adipocytes. C57/BL/6N mice were induced to obesity with a high-fat diet, and BSE was administered to confirm the effect on an animal model. Weight gain, morphological changes in adipose tissue, changes in the food efficiency ratio, and blood biochemical changes were observed, and an improvement effect on fatty liver was confirmed. As a result, the anti-obesity effect of BSE was confirmed in vitro, and it was confirmed that this effect was also effective in vivo and that it could be helpful in the treatment of obesity-related diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Metabolites Año: 2021 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Metabolites Año: 2021 Tipo del documento: Article Pais de publicación: Suiza