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Genomic characterization of hepatoid tumors: context matters.
Lawlor, Rita T; Mafficini, Andrea; Sciammarella, Concetta; Cantù, Cinzia; Rusev, Borislav C; Piredda, Maria L; Antonello, Davide; Grimaldi, Sonia; Bonizzato, Giada; Sperandio, Nicola; Marchegiani, Giovanni; Malleo, Giuseppe; Pea, Antonio; Salvia, Roberto; Mombello, Aldo; Mazzoleni, Guido; Nottegar, Alessia; Hanspeter, Esther; Riva, Giulio; Tomezzoli, Anna; Bencivenga, Maria; de Manzoni, Giovanni; Pedron, Serena; Paolino, Gaetano; Mattiolo, Paola; Brosens, Lodewijk A; Silvestris, Nicola; Fassan, Matteo; Cooke, Susanna L; Beer, Philip A; Milella, Michele; Adsay, Volkan N; Cheng, Liang; Scarpa, Aldo; Luchini, Claudio.
Afiliación
  • Lawlor RT; ARC-Net Research Center for Applied Research on Cancer, University of Verona, 37134 Verona, Italy.
  • Mafficini A; ARC-Net Research Center for Applied Research on Cancer, University of Verona, 37134 Verona, Italy; Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, 37134 Verona, Italy.
  • Sciammarella C; ARC-Net Research Center for Applied Research on Cancer, University of Verona, 37134 Verona, Italy.
  • Cantù C; Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, 37134 Verona, Italy.
  • Rusev BC; ARC-Net Research Center for Applied Research on Cancer, University of Verona, 37134 Verona, Italy.
  • Piredda ML; Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, 37134 Verona, Italy.
  • Antonello D; Department of Surgery, The Pancreas Institute, University and Hospital Trust of Verona, 37134 Verona, Italy.
  • Grimaldi S; ARC-Net Research Center for Applied Research on Cancer, University of Verona, 37134 Verona, Italy.
  • Bonizzato G; ARC-Net Research Center for Applied Research on Cancer, University of Verona, 37134 Verona, Italy.
  • Sperandio N; ARC-Net Research Center for Applied Research on Cancer, University of Verona, 37134 Verona, Italy.
  • Marchegiani G; Department of Surgery, The Pancreas Institute, University and Hospital Trust of Verona, 37134 Verona, Italy.
  • Malleo G; Department of Surgery, The Pancreas Institute, University and Hospital Trust of Verona, 37134 Verona, Italy.
  • Pea A; Department of Surgery, The Pancreas Institute, University and Hospital Trust of Verona, 37134 Verona, Italy.
  • Salvia R; Department of Surgery, The Pancreas Institute, University and Hospital Trust of Verona, 37134 Verona, Italy.
  • Mombello A; ARC-Net Research Center for Applied Research on Cancer, University of Verona, 37134 Verona, Italy.
  • Mazzoleni G; Department of Pathology, Central Hospital of Bolzano, 39100 Bolzano, Italy.
  • Nottegar A; Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, 37134 Verona, Italy.
  • Hanspeter E; Department of Pathology, Central Hospital of Bolzano, 39100 Bolzano, Italy.
  • Riva G; Department of Diagnostics, Pathology Unit, San Bortolo Hospital, 36100 Vicenza, Italy.
  • Tomezzoli A; Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, 37134 Verona, Italy.
  • Bencivenga M; Unit of General and Upper GI Surgery, University of Verona, 37134 Verona, Italy.
  • de Manzoni G; Unit of General and Upper GI Surgery, University of Verona, 37134 Verona, Italy.
  • Pedron S; Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, 37134 Verona, Italy.
  • Paolino G; Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, 37134 Verona, Italy.
  • Mattiolo P; Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, 37134 Verona, Italy.
  • Brosens LA; Department of Pathology, University Medical Center Utrecht, Utrecht University, 3584 CX Utrecht, the Netherlands; Department of Pathology, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands.
  • Silvestris N; IRCCS Istituto Tumori "Giovanni Paolo II" of Bari, and Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro", 70121 Bari, Italy.
  • Fassan M; Department of Medicine (DIMED), University of Padua, 35121 Padua, Italy.
  • Cooke SL; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Bearsden, G61 1QH Glasgow, UK.
  • Beer PA; Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Bearsden, G61 1QH Glasgow, UK; Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA Cambridge, UK.
  • Milella M; Department of Medicine, Section of Oncology, University and Hospital Trust of Verona, 37134 Verona, Italy.
  • Adsay VN; Department of Pathology, Koç University Hospital and Koç University Research Center for Translational Medicine (KUTTAM), 34010 Istanbul, Turkey.
  • Cheng L; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 46202 Indianapolis, IN, USA.
  • Scarpa A; ARC-Net Research Center for Applied Research on Cancer, University of Verona, 37134 Verona, Italy; Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, 37134 Verona, Italy. Electronic address: aldo.scarpa@univr.it.
  • Luchini C; ARC-Net Research Center for Applied Research on Cancer, University of Verona, 37134 Verona, Italy; Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, 37134 Verona, Italy. Electronic address: claudio.luchini@univr.it.
Hum Pathol ; 118: 30-41, 2021 12.
Article en En | MEDLINE | ID: mdl-34562502
Hepatoid tumors (HT) are rare neoplasms morphologically resembling hepatocellular carcinoma, which arise in several organs other than the liver. A comprehensive molecular profile of this group of neoplasms is still lacking. Genomic characterization of 19 HTs from different organs (three colon HTs, four esophagogastric HTs, four biliary HTs, six genitourinary HTs, two lung HTs) was performed using a multigene next-generation sequencing panel. NGS unraveled a composite molecular profile of HT. Their genetic alterations were clearly clustered by tumor site: (i) colorectal HT displayed microsatellite instability, high tumor mutational burden, mutations in ARID1A/B genes and NCOA4-RET gene fusion (2/3 cases); (ii) gastric HT had TP53 mutations (2/4); (iii) biliary HT displayed loss of CDKN2A (3/4) and loss of chromosome 18 (2/4); (iv) genital HT showed gain of chromosome 12 (3/6); (v) lung HT had STK11 somatic mutations (2/2). The only commonly mutated gene occurring in HT of different sites was TP53 (8/19 cases: colon 2, esophagogastric 2, biliary 2, genital 1, lungs 1). This study shows that most genetic alterations of HT were clustered by site, indicating that context matters. The novel potential targets for HT precision oncology are also clustered based on the anatomic origin. This study shed light on the biology of these rare cancers and may have important consequences for treatment decisions and clinical trial selection for HT patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma / Neoplasias Urogenitales / Neoplasias del Sistema Digestivo / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Hum Pathol Asunto de la revista: PATOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma / Neoplasias Urogenitales / Neoplasias del Sistema Digestivo / Neoplasias Pulmonares Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Hum Pathol Asunto de la revista: PATOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos