Your browser doesn't support javascript.
loading
Association of sensory phenotype with quality of life, functionality, and emotional well-being in patients suffering from neuropathic pain.
Gierthmühlen, Janne; Böhmer, Johann; Attal, Nadine; Bouhassira, Didier; Freynhagen, Rainer; Haanpää, Maija; Hansson, Per; Jensen, Troels Staehelin; Kennedy, Jeffrey; Maier, Christoph; Rice, Andrew S C; Sachau, Juliane; Segerdahl, Märta; Sindrup, Sören; Tölle, Thomas; Treede, Rolf-Detlef; Ventzel, Lise; Vollert, Jan; Baron, Ralf.
Afiliación
  • Gierthmühlen J; Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital of Schleswig-Holstein, Campus Kiel, Germany.
  • Böhmer J; Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital of Schleswig-Holstein, Campus Kiel, Germany.
  • Attal N; Inserm U987, APHP, UVSQ, Paris-Saclay University, CHU Ambroise Pare, Boulogne-Billancourt, France.
  • Bouhassira D; Inserm U987, APHP, UVSQ, Paris-Saclay University, CHU Ambroise Pare, Boulogne-Billancourt, France.
  • Freynhagen R; Department of Anaesthesiology, Critical Care Medicine, Pain Therapy & Palliative Care, Pain Center Lake Starnberg, Benedictus Hospital Feldafing, Germany.
  • Haanpää M; Department of Anaesthesiology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
  • Hansson P; Department of Neurosurgery, Helsinki University Central Hospital (HUCH), Helsinki, Finland.
  • Jensen TS; Department of Pain Management and Research, Norwegian National Advisory Unit on Neuropathic Pain, Division of Emergencies and Critical Care, Oslo University Hospital, Oslo, Norway.
  • Kennedy J; Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
  • Maier C; Department of Clinical Medicine, Neurological Research and Dansih Pain Research Center, Aarhus University Hospital, Aarhus, Denmark.
  • Rice ASC; Eli Lilly and Company, Indianapolis, IN, United States.
  • Sachau J; University Hospital of Pediatrics and Adolescent Medicine, Ruhr-University Bochum, Germany.
  • Segerdahl M; Pain Research, Department of Surgery and Cancer, Faculty of Medicine, Imperial College, London, United Kingdom.
  • Sindrup S; Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital of Schleswig-Holstein, Campus Kiel, Germany.
  • Tölle T; Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden and MS Medical Consulting, Stockholm, Sweden.
  • Treede RD; Department of Neurology, Odense University Hospital OUH, Odense, Denmark.
  • Ventzel L; Department of Neurology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
  • Vollert J; Neurophysiology, Mannheim Center for Translational Neurosciences (MCTN), Medical Faculty Mannheim, Heidelberg University, Heidelberg, Germany.
  • Baron R; Department of Pain Management and Research, Norwegian National Advisory Unit on Neuropathic Pain, Division of Emergencies and Critical Care, Oslo University Hospital, Oslo, Norway.
Pain ; 163(7): 1378-1387, 2022 07 01.
Article en En | MEDLINE | ID: mdl-34561391
ABSTRACT: Neuropathic pain highly affects quality of life, well-being, and function. It has recently been shown based on cluster analysis studies that most patients with neuropathic pain may be categorized into 1 of 3 sensory phenotypes: sensory loss, mechanical hyperalgesia, and thermal hyperalgesia. If these phenotypes reflect underlying pathophysiological mechanisms, they may be more relevant for patient management than underlying neurological diagnosis or pain intensity. The aim of this study was thus to examine the impact of these sensory phenotypes on mental health, functionality, and quality of life. Data of 433 patients from the IMI/EuroPain network database were analyzed, and results of HADS-D/A, Pain Catastrophizing Scale, Euro Quality of Life 5D/-VAS, Brief Pain Inventory, and Graded Chronic Pain Scale between the sensory phenotypes were compared using multiple regression analysis. There was no difference in chronic pain grade, pain intensity, depression, or anxiety scores between phenotypes. Pain interference (Brief Pain Inventory) was higher (P = 0.002); self-reported health state lower (Euro Quality of Life 5D VAS, P = 0.02); and problems regarding mobility (P = 0.008), usual activities (P = 0.004), and self-care (P = 0.039) more prominent (EQ5-D) in the sensory loss compared with the thermal hyperalgesia phenotype. Patients with sensory loss also showed higher pain catastrophizing scores (P = 0.006 and 0.022, respectively) compared with the 2 other groups. Sensory phenotype is associated with the impact of neuropathic pain conditions on well-being, daily functionality, and quality of life but is less associated with pain intensity. These results suggest that the somatosensory phenotype should be considered for personalized pain management.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor Crónico / Neuralgia Tipo de estudio: Risk_factors_studies Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Pain Año: 2022 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor Crónico / Neuralgia Tipo de estudio: Risk_factors_studies Aspecto: Patient_preference Límite: Humans Idioma: En Revista: Pain Año: 2022 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos