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M ycoplasma pneumoniae carriage evades induction of protective mucosal antibodies.
de Groot, Ruben Cornelis Anthonie; Estevão, Silvia Cristina; Meyer Sauteur, Patrick Michael; Perkasa, Aditya; Hoogenboezem, Theo; Spuesens, Emiel Benny Margriet; Verhagen, Lilly Maria; van Rossum, Anna Maria Christiane; Unger, Wendy Wilhelmina Josephina.
Afiliación
  • de Groot RCA; Dept of Pediatrics, Laboratory of Pediatrics, Erasmus MC University Medical Centre Rotterdam - Sophia Children's Hospital, Rotterdam, The Netherlands.
  • Estevão SC; Dept of Pediatrics, Laboratory of Pediatrics, Erasmus MC University Medical Centre Rotterdam - Sophia Children's Hospital, Rotterdam, The Netherlands.
  • Meyer Sauteur PM; Division of Infectious Diseases and Hospital Epidemiology, University Children's Hospital Zurich, Zurich, Switzerland.
  • Perkasa A; Dept of Pediatrics, Laboratory of Pediatrics, Erasmus MC University Medical Centre Rotterdam - Sophia Children's Hospital, Rotterdam, The Netherlands.
  • Hoogenboezem T; Dept of Pediatrics, Van Weel Bethesda Hospital, Dirksland, The Netherlands.
  • Spuesens EBM; Dept of Pediatrics, Laboratory of Pediatrics, Erasmus MC University Medical Centre Rotterdam - Sophia Children's Hospital, Rotterdam, The Netherlands.
  • Verhagen LM; Dept of Pediatrics, Immunology and Infectious Diseases, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht, The Netherlands.
  • van Rossum AMC; Dept of Pediatrics, Division of Paediatric Infectious Diseases and Immunology, Erasmus MC University Medical Centre Rotterdam - Sophia Children's Hospital, Rotterdam, The Netherlands.
  • Unger WWJ; Dept of Pediatrics, Laboratory of Pediatrics, Erasmus MC University Medical Centre Rotterdam - Sophia Children's Hospital, Rotterdam, The Netherlands w.unger@erasmusmc.nl.
Eur Respir J ; 59(4)2022 04.
Article en En | MEDLINE | ID: mdl-34561284
BACKGROUND: Mycoplasma pneumoniae is the most common bacterial cause of pneumonia in children hospitalised for community-acquired pneumonia (CAP). Prevention of infection by vaccines may be an important strategy in the presence of emerging macrolide-resistant M. pneumoniae. However, knowledge of immune responses to M. pneumoniae is limited, complicating vaccine design. METHODS: We studied the antibody response during M. pneumoniae respiratory tract infection and asymptomatic carriage in two different cohorts. RESULTS: In a nested case-control study (n=80) of M. pneumoniae carriers and matched controls we observed that carriage by M. pneumoniae does not lead to a rise in either mucosal or systemic M. pneumoniae-specific antibodies, even after months of persistent carriage. We replicated this finding in a second cohort (n=69) and also found that during M. pneumoniae CAP, mucosal levels of M. pneumoniae-specific IgA and IgG did increase significantly. In vitro adhesion assays revealed that high levels of M. pneumoniae-specific antibodies in nasal secretions of paediatric patients prevented the adhesion of M. pneumoniae to respiratory epithelial cells. CONCLUSIONS: Our study demonstrates that M. pneumoniae-specific mucosal antibodies protect against bacterial adhesion to respiratory epithelial cells, and are induced only during M. pneumoniae infection and not during asymptomatic carriage. This is strikingly different from carriage with bacteria such as Streptococcus pneumoniae where mucosal antibodies are induced by bacterial carriage.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía / Neumonía por Mycoplasma / Infecciones Comunitarias Adquiridas Tipo de estudio: Observational_studies Límite: Child / Humans Idioma: En Revista: Eur Respir J Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía / Neumonía por Mycoplasma / Infecciones Comunitarias Adquiridas Tipo de estudio: Observational_studies Límite: Child / Humans Idioma: En Revista: Eur Respir J Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido