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Social and Educational Outcomes in Patients With Biliary Atresia: A Systematic Review.
Alexander, Emma C; Greaves, William; Vaidya, Hrisheekesh J; Burford, Charlotte; Jain, Vandana; Samyn, Marianne.
Afiliación
  • Alexander EC; Paediatric Liver, GI and Nutrition Centre and Mowatlabs, Kings College Hospital.
  • Greaves W; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London.
  • Vaidya HJ; University College London Medical School, University College London.
  • Burford C; Northwick Park Hospital, London North West University Healthcare NHS Trust, London.
  • Jain V; Northwick Park Hospital, London North West University Healthcare NHS Trust, London.
  • Samyn M; Paediatric Liver, GI and Nutrition Centre and Mowatlabs, Kings College Hospital.
J Pediatr Gastroenterol Nutr ; 74(1): 104-109, 2022 01 01.
Article en En | MEDLINE | ID: mdl-34560722
OBJECTIVES: To systematically review the social outcomes of patients with biliary atresia (BA), including educational, employment and family outcomes. METHODS: We conducted a systematic review of Medline, EMBASE, Global Health, Maternity and Infant Care Database, supplemented by reference searching. National Heart, Lung and Blood Institute scoring was conducted for quality assessment. The PROSPERO registration ID was CRD42020178846. RESULTS: Fifty-one studies were included (41 cohort, 10 cross-sectional), including 4631 participants across 16 countries. Cohorts were BA post-liver transplant (LT) (18 studies), native liver survivors (NLS) (16 studies), mixed (13 studies) and four other cohorts. Outcomes covered; education (n = 35), employment (n = 16), family outcomes (n = 22), and social functioning (n = 22). BA patients had lower school functioning scores than controls, with no difference between NLS versus post-LT. Between 2% and 48% of children required additional educational support. Between 60% and 100% of adult patients with BA were employed. Pregnancies were described in 17 studies, with small samples, and some noted complications. Social functioning scores were similar to healthy controls in 8 of 11 comparisons. CONCLUSIONS: Despite BA being the primary indication for liver transplantation in childhood, social outcomes for children and adolescents are predominantly reported in non-controlled, single-centre survey-based studies. School functioning is lower compared to peer groups, with no evidence of a difference for those having a liver transplant. We recommend routine psychosocial assessment of these patients during follow-up, alongside multi-centre collaborations, to maximise the quality of evidence for future patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Atresia Biliar / Trasplante de Hígado Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Risk_factors_studies / Systematic_reviews Límite: Adolescent / Adult / Child / Female / Humans / Infant / Pregnancy Idioma: En Revista: J Pediatr Gastroenterol Nutr Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Atresia Biliar / Trasplante de Hígado Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Risk_factors_studies / Systematic_reviews Límite: Adolescent / Adult / Child / Female / Humans / Infant / Pregnancy Idioma: En Revista: J Pediatr Gastroenterol Nutr Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos