Your browser doesn't support javascript.
loading
Antimicrobial susceptibility of Neisseria gonorrhoeae isolates and syndromic treatment of men with urethral discharge in Kingston, Jamaica, 2018-19.
Cameron-McDermott, Suzette M; Barrow, Geoffrey J; Webster, Alicia M; De La Haye, Carrington O; Wood, Denise H E; Lewis, Violet M; Nicholson, Alison; Reynolds-Campbell, Glendee Y; Thoms-Rodriguez, Camille-Ann A; Roye-Green, Karen J; Otto-Stewart, Nakeisha; Miller, Zahra N; Tomlinson, Jennifer A; Skyers, Nicola; Unemo, Magnus; Anzinger, Joshua J.
Afiliación
  • Cameron-McDermott SM; Department of Microbiology, Faculty of Medical Sciences, University of the West Indies, Mona, Kingston, Jamaica.
  • Barrow GJ; Department of Medicine, Faculty of Medical Sciences, University of the West Indies, Mona, Kingston, Jamaica.
  • Webster AM; Comprehensive Health Centre STI Clinic, Kingston, Jamaica.
  • De La Haye CO; Comprehensive Health Centre STI Clinic, Kingston, Jamaica.
  • Wood DHE; Comprehensive Health Centre STI Clinic, Kingston, Jamaica.
  • Lewis VM; Comprehensive Health Centre STI Clinic, Kingston, Jamaica.
  • Nicholson A; Department of Microbiology, Faculty of Medical Sciences, University of the West Indies, Mona, Kingston, Jamaica.
  • Reynolds-Campbell GY; Department of Microbiology, Faculty of Medical Sciences, University of the West Indies, Mona, Kingston, Jamaica.
  • Thoms-Rodriguez CA; Department of Microbiology, Faculty of Medical Sciences, University of the West Indies, Mona, Kingston, Jamaica.
  • Roye-Green KJ; Department of Microbiology, Faculty of Medical Sciences, University of the West Indies, Mona, Kingston, Jamaica.
  • Otto-Stewart N; Department of Microbiology, Faculty of Medical Sciences, University of the West Indies, Mona, Kingston, Jamaica.
  • Miller ZN; Epidemiology Unit, Ministry of Health and Wellness, Kingston, Jamaica.
  • Tomlinson JA; HIV/STI/TB Unit, Ministry of Health and Wellness, Kingston, Jamaica.
  • Skyers N; Jamaica AIDS Support for Life, Kingston, Jamaica.
  • Unemo M; HIV/STI/TB Unit, Ministry of Health and Wellness, Kingston, Jamaica.
  • Anzinger JJ; WHO Collaborating Centre for Gonorrhoea and Other STIs, Department of Laboratory Medicine, Örebro University and University Hospital, Örebro, Sweden.
J Antimicrob Chemother ; 77(1): 218-222, 2021 12 24.
Article en En | MEDLINE | ID: mdl-34557895
OBJECTIVES: To quantitatively determine the antimicrobial susceptibility of clinical Neisseria gonorrhoeae isolates from men with urethral discharge in Jamaica and to describe the syndromic treatment therapies administered. METHODS: Urethral eSwabs (Copan) were collected from 175 men presenting with urethral discharge to the Comprehensive Health Centre STI Clinic, Kingston, Jamaica. Clinical information was collected and MICs of eight antimicrobials were determined for N. gonorrhoeae isolates (n = 96) using Etest and interpreted using CLSI criteria. RESULTS: The median age of the subjects was 28 years (range: 18-73 years) with a median of 2 sexual partners (range: 1-25) per male in the previous 3 months. All examined N. gonorrhoeae isolates were susceptible to ceftriaxone (96/96), azithromycin (91/91), cefixime (91/91) and spectinomycin (91/91). For ciprofloxacin and gentamicin, respectively, 98.9% (91/92) and 91.3% (84/92) of the isolates were susceptible and 1.1% (1/92) and 8.7% (8/92) showed intermediate susceptibility/resistance. For tetracycline and benzylpenicillin, respectively, 38.0% (35/92) and 22.0% (20/91) of the isolates were susceptible, 52.2% (48/92) and 74.7% (68/91) showed intermediate susceptibility/resistance and 9.8% (9/92) and 3.3% (3/91) were resistant. Syndromic treatment was administered as follows: 93.1% received 250 mg of ceftriaxone intramuscularly plus 100 mg of doxycycline orally q12h for 1-2 weeks and 6.9% received 500 mg of ciprofloxacin orally plus 100 mg of doxycycline orally q12h for 1 week. CONCLUSIONS: Ceftriaxone (250 mg) remains appropriate for gonorrhoea treatment in the examined population of men in Kingston, Jamaica. Surveillance of N. gonorrhoeae AMR should be expanded in Jamaica and other Caribbean countries to guide evidence-based treatment guidelines.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Gonorrea / Neisseria gonorrhoeae Tipo de estudio: Guideline Límite: Child / Child, preschool / Humans / Infant / Male País/Región como asunto: Caribe ingles / Jamaica Idioma: En Revista: J Antimicrob Chemother Año: 2021 Tipo del documento: Article País de afiliación: Jamaica Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Gonorrea / Neisseria gonorrhoeae Tipo de estudio: Guideline Límite: Child / Child, preschool / Humans / Infant / Male País/Región como asunto: Caribe ingles / Jamaica Idioma: En Revista: J Antimicrob Chemother Año: 2021 Tipo del documento: Article País de afiliación: Jamaica Pais de publicación: Reino Unido