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5-HT2C agonists and antagonists block different components of behavioral responses to potential, distal, and proximal threat in zebrafish.
do Carmo Silva, Rhayra Xavier; do Nascimento, Bianca Gomes; Gomes, Gabriela Cristini Vidal; da Silva, Nadyme Assad Holanda; Pinheiro, Jéssica Souza; da Silva Chaves, Suianny Nayara; Pimentel, Ana Flávia Nogueira; Costa, Bruna Patrícia Dutra; Herculano, Anderson Manoel; Lima-Maximino, Monica; Maximino, Caio.
Afiliación
  • do Carmo Silva RX; Laboratório de Neurofarmacologia Experimental - LNE, Universidade Federal do Pará, Belém/PA, Brazil; Laboratório de Neurociências e Comportamento "Frederico Guilherme Graeff" - LaNeC, Universidade Federal do Sul e Sudeste do Pará, Marabá/PA, Brazil.
  • do Nascimento BG; Laboratório de Neurociências e Comportamento "Frederico Guilherme Graeff" - LaNeC, Universidade Federal do Sul e Sudeste do Pará, Marabá/PA, Brazil.
  • Gomes GCV; Laboratório de Neurociências e Comportamento "Frederico Guilherme Graeff" - LaNeC, Universidade Federal do Sul e Sudeste do Pará, Marabá/PA, Brazil.
  • da Silva NAH; Laboratório de Neurofarmacologia Experimental - LNE, Universidade Federal do Pará, Belém/PA, Brazil.
  • Pinheiro JS; Laboratório de Neurofarmacologia Experimental - LNE, Universidade Federal do Pará, Belém/PA, Brazil.
  • da Silva Chaves SN; Laboratório de Neurociências e Comportamento "Frederico Guilherme Graeff" - LaNeC, Universidade Federal do Sul e Sudeste do Pará, Marabá/PA, Brazil.
  • Pimentel AFN; Laboratório de Neurociências e Comportamento "Frederico Guilherme Graeff" - LaNeC, Universidade Federal do Sul e Sudeste do Pará, Marabá/PA, Brazil.
  • Costa BPD; Laboratório de Neurociências e Comportamento "Frederico Guilherme Graeff" - LaNeC, Universidade Federal do Sul e Sudeste do Pará, Marabá/PA, Brazil.
  • Herculano AM; Laboratório de Neurofarmacologia Experimental - LNE, Universidade Federal do Pará, Belém/PA, Brazil.
  • Lima-Maximino M; Laboratório de Neurofarmacologia e Biofísica - LaNeF, Universidade do Estado do Pará, Marabá/PA, Brazil.
  • Maximino C; Laboratório de Neurociências e Comportamento "Frederico Guilherme Graeff" - LaNeC, Universidade Federal do Sul e Sudeste do Pará, Marabá/PA, Brazil. Electronic address: cmaximino@unifesspa.edu.br.
Pharmacol Biochem Behav ; 210: 173276, 2021 11.
Article en En | MEDLINE | ID: mdl-34555392
Serotonin (5-HT) receptors have been implicated in responses to aversive stimuli in mammals and fish, but its precise role is still unknown. Moreover, since at least seven families of 5-HT receptors exist in vertebrates, the role of specific receptors is still debated. Aversive stimuli can be classified as indicators of proximal, distal, or potential threat, initiating responses that are appropriate for each of these threat levels. Responses to potential threat usually involve cautious exploration and increased alertness, while responses to distal and proximal threat involve a fight-flight-freeze reaction. We exposed adult zebrafish to a conspecific alarm substance (CAS) and observed behavior during (distal threat) and after (potential threat) exposure, and treated with the 5-HT2C receptor agonists MK-212 or WAY-161503 or with the antagonist RS-102221. The agonists blocked CAS-elicited defensive behavior (distal threat), but not post-exposure increases in defensive behavior (potential threat), suggesting inhibition of responses to distal threat. MK-212 blocked changes in freezing elicited by acute restraint stress, a model of proximal threat, while RS-102221 blocked changes in geotaxis elicited this stressor. We also found that RS-102221, a 5-HT2C receptor antagonist, produced small effect on behavior during and after exposure to CAS. Preprint: https://www.biorxiv.org/content/10.1101/2020.10.04.324202; Data and scripts: https://github.com/lanec-unifesspa/5-HT-CAS/tree/master/data/5HT2C.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conducta Animal / Reacción de Fuga / Miedo / Agonistas del Receptor de Serotonina 5-HT2 / Antagonistas del Receptor de Serotonina 5-HT2 Límite: Animals Idioma: En Revista: Pharmacol Biochem Behav Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conducta Animal / Reacción de Fuga / Miedo / Agonistas del Receptor de Serotonina 5-HT2 / Antagonistas del Receptor de Serotonina 5-HT2 Límite: Animals Idioma: En Revista: Pharmacol Biochem Behav Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos