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A molecular communication channel consisting of a single reversible chain of hydrogen bonds in a conformationally flexible oligomer.
Morris, David T J; Wales, Steven M; Tilly, David P; Farrar, Elliot H E; Grayson, Matthew N; Ward, John W; Clayden, Jonathan.
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  • Morris DTJ; School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK.
  • Wales SM; School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK.
  • Tilly DP; School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK.
  • Farrar EHE; Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK.
  • Grayson MN; Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK.
  • Ward JW; School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK.
  • Clayden J; School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK.
Chem ; 7(9): 2460-2472, 2021 Sep 09.
Article en En | MEDLINE | ID: mdl-34553103
Communication of information through the global switching of conformation in synthetic molecules has hitherto entailed the inversion of chirality. Here, we report a class of oligomer through which information may be communicated through a global reversal of polarity. Ethylene-bridged oligoureas are constitutionally symmetrical, conformationally flexible molecules organized by a single chain of hydrogen bonds running the full length of the oligomer. NMR reveals that this hydrogen-bonded chain may undergo a coherent reversal of directionality. The directional uniformity of the hydrogen-bond chain allows it to act as a channel for the spatial communication of information on a molecular scale. A binding site at the terminus of an oligomer detects local information about changes in pH or anion concentration and transmits that information-in the form of a directionality switch in the hydrogen-bond chain-to a remote polarity-sensitive fluorophore. This propagation of polarity-encoded information provides a new mechanism for molecular communication.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos