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The Underestimated Role of Mast Cells in the Pathogenesis of Rhinopathies.
Gelardi, Matteo; Giancaspro, Rossana; Cassano, Michele; Ribatti, Domenico.
Afiliación
  • Gelardi M; Unit of Otolaryngology, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
  • Giancaspro R; Unit of Otolaryngology, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
  • Cassano M; Unit of Otolaryngology, Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.
  • Ribatti D; Department of Basic Medical Sciences, Neurosciences and Sensory Organs, University of Bari Medical School, Bari, Italy.
Int Arch Allergy Immunol ; 183(2): 153-159, 2022.
Article en En | MEDLINE | ID: mdl-34551414
Mast cells (MCs) are involved in several biological processes, such as defense against pathogens, immunomodulation, tissue repair after injury, and angiogenesis. MCs have been shown to change from protective immune cells to potent pro-inflammatory cells, influencing the progression of many pathological conditions, including autoimmune diseases and cancers. The role of MCs in the pathogenesis of rhinopathies has often been underestimated, since previous studies have focused their attention on eosinophils and neutrophils, while MCs were considered involved exclusively in allergic rhinitis. However, recent nasal cytology findings have shown the involvement of MCs in several rhinopathies, such as NARMA, NARESMA, and CRSwNP. These recent evidences highlight the crucial role that MCs play in orchestrating the inflammation of the nasal mucosa, through complex biological mechanisms, not yet fully understood. In this context, a better understanding of these mechanisms is fundamental for practicing Precision Medicine, which requires careful population selection and stratification into subgroups based on the phenotype/endotype of the patients, in order to guarantee the patient a tailored therapy. Based on this background, further studies are needed to understand the pathophysiological mechanisms involving MCs and, consequently, to develop targeted therapies aimed to obtain a selective inhibition of tissue remodeling and preventing MC-mediated immune suppression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Faríngeas / Susceptibilidad a Enfermedades / Mastocitos Tipo de estudio: Diagnostic_studies / Etiology_studies Límite: Animals / Humans Idioma: En Revista: Int Arch Allergy Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Faríngeas / Susceptibilidad a Enfermedades / Mastocitos Tipo de estudio: Diagnostic_studies / Etiology_studies Límite: Animals / Humans Idioma: En Revista: Int Arch Allergy Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza