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Spectral changes following resective epilepsy surgery and neurocognitive function in children with epilepsy.
Arski, Olivia N; Wong, Simeon M; Warsi, Nebras M; Martire, Daniel J; Ochi, Ayako; Otsubo, Hiroshi; Donner, Elizabeth; Jain, Puneet; Kerr, Elizabeth N; Smith, Mary Lou; Ibrahim, George M.
Afiliación
  • Arski ON; Program in Neuroscience and Mental Health, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
  • Wong SM; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
  • Warsi NM; Program in Neuroscience and Mental Health, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
  • Martire DJ; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
  • Ochi A; Program in Neuroscience and Mental Health, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
  • Otsubo H; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
  • Donner E; Division of Neurosurgery, Hospital for Sick Children, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
  • Jain P; Program in Neuroscience and Mental Health, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
  • Kerr EN; Division of Neurology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
  • Smith ML; Division of Neurology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
  • Ibrahim GM; Division of Neurology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
J Neurophysiol ; 126(5): 1614-1621, 2021 Nov 01.
Article en En | MEDLINE | ID: mdl-34550020
Decelerated resting cortical oscillations, high-frequency activity, and enhanced cross-frequency interactions are features of focal epilepsy. The association between electrophysiological signal properties and neurocognitive function, particularly following resective surgery, is, however, unclear. In the current report, we studied intraoperative recordings from intracranial electrodes implanted in seven children with focal epilepsy and analyzed the spectral dynamics both before and after surgical resection of the hypothesized seizure focus. The associations between electrophysiological spectral signatures and each child's neurocognitive profiles were characterized using a partial least squares analysis. We find that extent of spectral alteration at the periphery of surgical resection, as indexed by slowed resting frequency and its acceleration following surgery, is associated with baseline cognitive deficits in children. The current report provides evidence supporting the relationship between altered spectral properties in focal epilepsy and neuropsychological deficits in children. In particular, these findings suggest a critical role of disrupted thalamocortical rhythms, which are believed to underlie the spectral alterations we describe, in both epileptogenicity and neurocognitive function.NEW & NOTEWORTHY Spectral alterations marked by decelerated resting oscillations and ectopic high-frequency activity have been noted in focal epilepsy. We leveraged intraoperative recordings from chronically implanted electrodes pre- and postresection to understand the association between these electrophysiological phenomena and neuropsychological function. We find that the extent of spectral alteration, indexed by slowed resting frequency and its acceleration following resection, is associated with baseline cognitive deficits. These findings provide novel insights into neurocognitive impairments in focal epilepsy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Epilepsias Parciales / Ondas Encefálicas / Disfunción Cognitiva / Monitorización Neurofisiológica Intraoperatoria / Electrocorticografía Tipo de estudio: Etiology_studies Límite: Child / Humans Idioma: En Revista: J Neurophysiol Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Epilepsias Parciales / Ondas Encefálicas / Disfunción Cognitiva / Monitorización Neurofisiológica Intraoperatoria / Electrocorticografía Tipo de estudio: Etiology_studies Límite: Child / Humans Idioma: En Revista: J Neurophysiol Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos