Your browser doesn't support javascript.
loading
Inflammatory Biomarkers and Intracranial Hemorrhage after Endovascular Thrombectomy.
Diestro, Jose Danilo Bengzon; Parra-Farinas, Carmen; Balas, Michael; Zador, Zsolt; Almusalam, Noora; Dmytriw, Adam A; Rajendram, Phavalan; Phillips, Rebecca; Alqabbani, Abdullah; Qazi, Emmad; Li, Yangmei; Montanera, Walter; Sarma, Dipanka; Marotta, Thomas R; Bharatha, Aditya; Spears, Julian.
Afiliación
  • Diestro JDB; Division of Diagnostic and Therapeutic Neuroradiology, Department of Medical Imaging, St. Michael's Hospital, University of Toronto, Toronto, Canada.
  • Parra-Farinas C; Division of Diagnostic and Therapeutic Neuroradiology, Department of Medical Imaging, St. Michael's Hospital, University of Toronto, Toronto, Canada.
  • Balas M; Division of Neurosurgery, Department of Surgery, St. Michael's Hospital, University of Toronto, Toronto, Canada.
  • Zador Z; Division of Neurosurgery, Department of Surgery, St. Michael's Hospital, University of Toronto, Toronto, Canada.
  • Almusalam N; Division of Neurology, Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, Canada.
  • Dmytriw AA; Department of Medical Imaging, St. Michael's Hospital, University of Toronto, Toronto, Canada.
  • Rajendram P; Division of Neurology, Department of Medicine, St. Michael's Hospital, University of Toronto, Toronto, Canada.
  • Phillips R; Cumming School of Medicine, University of Calgary, Calgary, Canada.
  • Alqabbani A; Department of Medical Imaging, St. Michael's Hospital, University of Toronto, Toronto, Canada.
  • Qazi E; Department of Medical Imaging, St. Michael's Hospital, University of Toronto, Toronto, Canada.
  • Li Y; Division of Neurosurgery, Department of Surgery, St. Michael's Hospital, University of Toronto, Toronto, Canada.
  • Montanera W; Division of Diagnostic and Therapeutic Neuroradiology, Department of Medical Imaging, St. Michael's Hospital, University of Toronto, Toronto, Canada.
  • Sarma D; Division of Neurosurgery, Department of Surgery, St. Michael's Hospital, University of Toronto, Toronto, Canada.
  • Marotta TR; Division of Diagnostic and Therapeutic Neuroradiology, Department of Medical Imaging, St. Michael's Hospital, University of Toronto, Toronto, Canada.
  • Bharatha A; Division of Neurosurgery, Department of Surgery, St. Michael's Hospital, University of Toronto, Toronto, Canada.
  • Spears J; Division of Diagnostic and Therapeutic Neuroradiology, Department of Medical Imaging, St. Michael's Hospital, University of Toronto, Toronto, Canada.
Can J Neurol Sci ; 49(5): 644-650, 2022 09.
Article en En | MEDLINE | ID: mdl-34548113
BACKGROUND: Intracranial hemorrhage after endovascular thrombectomy is associated with poorer prognosis compared with those who do not develop the complication. Our study aims to determine predictors of post-EVT hemorrhage - more specifically, inflammatory biomarkers present in baseline serology. METHODS: We performed a retrospective review of consecutive patients treated with EVT for acute large vessel ischemic stroke. The primary outcome of the study is the presence of ICH on the post-EVT scan. We used four definitions: the SITS-MOST criteria, the NINDS criteria, asymptomatic hemorrhage, and overall hemorrhage. We identified nonredundant predictors of outcome using backward elimination based on Akaike Information Criteria. We then assessed prediction accuracy using area under the receiver operating curve. Then we implemented variable importance ranking from logistic regression models using the drop in Naegelkerke R2 with the exclusion of each predictor. RESULTS: Our study demonstrates a 6.3% SITS (16/252) and 10.0% NINDS (25/252) sICH rate, as well as a 19.4% asymptomatic (49/252) and 29.4% (74/252) overall hemorrhage rate. Serologic markers that demonstrated association with post-EVT hemorrhage were: low lymphocyte count (SITS), high neutrophil count (NINDS, overall hemorrhage), low platelet to lymphocyte ratio (NINDS), and low total WBC (NINDS, asymptomatic hemorrhage). CONCLUSION: Higher neutrophil counts, low WBC counts, low lymphocyte counts, and low platelet to lymphoycyte ratio were baseline serology biomarkers that were associated with post-EVT hemorrhage. Our findings, particularly the association of diabetes mellitus and high neutrophil, support experimental data on the role of thromboinflammation in hemorrhagic transformation of large vessel occlusions.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trombosis / Isquemia Encefálica / Accidente Cerebrovascular / Procedimientos Endovasculares Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Can J Neurol Sci Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trombosis / Isquemia Encefálica / Accidente Cerebrovascular / Procedimientos Endovasculares Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Can J Neurol Sci Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido