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Successful pregnancy after ovulation induction with human chorionic gonadotropin in a woman with selective luteinising hormone deficiency.
Sasaki, Lizandra Moura Paravidine; de Carvalho, Bruno Ramalho; Silva, Adelino Amaral; Zaconeta, Alberto Moreno; da Silva Wanderley, Miriam; da Motta, Luiz Augusto Casulari Roxo; Lofrano-Porto, Adriana.
Afiliación
  • Sasaki LMP; Department of Women's Health, University Hospital of Brasília, Brasília, Brazil.
  • de Carvalho BR; Department of Postgraduate Program in Medical Sciences, Faculty of Medicine, University of Brasília, Brasília, Brazil.
  • Silva AA; Department of Women's Health, Sírio Libanês Hospital, Brasília, Brazil.
  • Zaconeta AM; Genesis-Human Reproduction Assistance Center, Brasília, Brazil.
  • da Silva Wanderley M; Department of Women's Health, University Hospital of Brasília, Brasília, Brazil.
  • da Motta LACR; Department of Gynecology and Obstetrics, Faculty of Medicine, University of Brasília, Brasília, Brazil.
  • Lofrano-Porto A; Department of Gynecology and Obstetrics, Faculty of Medicine, University of Brasília, Brasília, Brazil.
Hum Reprod ; 36(11): 2916-2920, 2021 10 18.
Article en En | MEDLINE | ID: mdl-34535998
Selective LH deficiency has been described in several men, but only in two women who presented normal pubertal development but secondary amenorrhoea due to anovulation. Despite its rarity, this condition represents a valuable model for studying the processes regulated by FSH or LH during late folliculogenesis and ovulation in humans. A woman previously diagnosed with selective LH deficiency due to a homozygous germline splice site mutation in LHB (IVS2 + 1G→C mutation) was submitted to an individualised ovarian induction protocol, first with recombinant LH and then with highly purified urinary hCG. Ovarian follicle growth and ovulation were achieved, and a healthy baby was born after an uneventful term pregnancy. The treatment described herein demonstrates that the clinical actions of exogenous LH or hCG in inducing late-stage follicular development in women with deficient LH production or performance might be interchangeable or inevitable, once FSH-dependent early follicular growth is assured.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Gonadotropina Coriónica / Anovulación Tipo de estudio: Guideline / Prognostic_studies Límite: Female / Humans / Male / Pregnancy Idioma: En Revista: Hum Reprod Asunto de la revista: MEDICINA REPRODUTIVA Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Gonadotropina Coriónica / Anovulación Tipo de estudio: Guideline / Prognostic_studies Límite: Female / Humans / Male / Pregnancy Idioma: En Revista: Hum Reprod Asunto de la revista: MEDICINA REPRODUTIVA Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido