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Microwave ablation for colorectal cancer metastasis to the liver: a single-center retrospective analysis.
Knott, Emily A; Ziemlewicz, Timothy J; Lubner, Sam J; Swietlik, John F; Weber, Sharon M; Zlevor, Annie M; Longhurst, Colin; Hinshaw, J Louis; Lubner, Meghan G; Mulkerin, Daniel L; Abbott, Daniel E; Deming, Dustin; LoConte, Noelle K; Uboha, Nataliya; Couillard, Allison B; Wells, Shane A; Laeseke, Paul F; Alexander, Marci L; Lee, Fred T.
Afiliación
  • Knott EA; Department of Radiology, University of Wisconsin-Madison, Madison, WI, USA.
  • Ziemlewicz TJ; Department of Radiology, University of Wisconsin-Madison, Madison, WI, USA.
  • Lubner SJ; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
  • Swietlik JF; Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA.
  • Weber SM; Department of Radiology, University of Wisconsin-Madison, Madison, WI, USA.
  • Zlevor AM; Department of Radiology, University of Wisconsin-Madison, Madison, WI, USA.
  • Longhurst C; Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA.
  • Hinshaw JL; Department of Surgery, University of Wisconsin-Madison, Madison, WI, USA.
  • Lubner MG; Department of Radiology, University of Wisconsin-Madison, Madison, WI, USA.
  • Mulkerin DL; Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA.
  • Abbott DE; Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, USA.
  • Deming D; Department of Radiology, University of Wisconsin-Madison, Madison, WI, USA.
  • LoConte NK; Department of Urology, University of Wisconsin-Madison, Madison, WI, USA.
  • Uboha N; Department of Radiology, University of Wisconsin-Madison, Madison, WI, USA.
  • Couillard AB; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
  • Wells SA; Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA.
  • Laeseke PF; Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI, USA.
  • Alexander ML; Department of Surgery, University of Wisconsin-Madison, Madison, WI, USA.
  • Lee FT; Department of Medicine, University of Wisconsin-Madison, Madison, WI, USA.
J Gastrointest Oncol ; 12(4): 1454-1469, 2021 Aug.
Article en En | MEDLINE | ID: mdl-34532102
BACKGROUND: The purpose of this study is to evaluate the safety and intermediate-term efficacy of percutaneous microwave (MW) ablation for the treatment of colorectal liver metastases (CRLM) at a single institution. METHODS: A retrospective review was performed of all CRLM treated with MW ablation from 3/2011 to 7/2020 (102 tumors; 72 procedures; 57 patients). Mean age was 60 years (range, 36-88) and mean tumor size was 1.8 cm (range, 0.5-5.0 cm). The patient population included 19 patients with extra-hepatic disease. Chemotherapy (pre- and/or post-ablation) was given in 98% of patients. Forty-five sessions were preceded by other focal CRLM treatments including resection, ablation, radiation, and radioembolization. Kaplan-Meier curves were used to estimate local tumor progression-free survival (LTPFS), disease-free survival (DFS), and overall survival (OS) and multivariate analysis (Cox Proportional Hazards model) was used to test predictors of OS. RESULTS: Technical success (complete ablation) was 100% and median follow-up was 42 months (range, 1-112). There was a 4% major complication rate and an overall complication rate of 8%. Local tumor progression (LTP) rate during the entire study period was 4/98 (4%), in which 2 were retreated with MW ablation for a secondary LTP-rate of 2%. LTP-free survival at 1, 3, and 5 years was 93%, 58%, and 39% and median LTP-free survival was 48 months. OS at 1, 3, and 5 years was 96%, 66%, 47% and median OS was 52 months. There were no statistically significant predictors of OS. CONCLUSIONS: MW ablation of hepatic colorectal liver metastases appears safe with excellent local tumor control and prolonged survival compared to historical controls in selected patients. Further comparative studies with other local treatment strategies appear indicated.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: J Gastrointest Oncol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: China
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: J Gastrointest Oncol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: China