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Single-cell immune profiling reveals distinct immune response in asymptomatic COVID-19 patients.
Zhao, Xiang-Na; You, Yue; Cui, Xiao-Ming; Gao, Hui-Xia; Wang, Guo-Lin; Zhang, Sheng-Bo; Yao, Lin; Duan, Li-Jun; Zhu, Ka-Li; Wang, Yu-Ling; Li, Li; Lu, Jian-Hua; Wang, Hai-Bin; Fan, Jing-Fang; Zheng, Huan-Wei; Dai, Er-Hei; Tian, Lu-Yi; Ma, Mai-Juan.
Afiliación
  • Zhao XN; Center for Disease Control and Prevention of Chinese People's Liberation Army, Beijing, China.
  • You Y; The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia.
  • Cui XM; Department of Medical Biology, The University of Melbourne, Parkville, Vic, Australia.
  • Gao HX; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
  • Wang GL; The Fifth Hospital of Shijiazhuang, Hebei Medical University, Shijiazhuang, China.
  • Zhang SB; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
  • Yao L; The Walter and Eliza Hall Institute of Medical Research, Parkville, Vic, Australia.
  • Duan LJ; Department of Medical Biology, The University of Melbourne, Parkville, Vic, Australia.
  • Zhu KL; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
  • Wang YL; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
  • Li L; State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
  • Lu JH; The Fifth Hospital of Shijiazhuang, Hebei Medical University, Shijiazhuang, China.
  • Wang HB; The Fifth Hospital of Shijiazhuang, Hebei Medical University, Shijiazhuang, China.
  • Fan JF; The Fifth Hospital of Shijiazhuang, Hebei Medical University, Shijiazhuang, China.
  • Zheng HW; The Fifth Hospital of Shijiazhuang, Hebei Medical University, Shijiazhuang, China.
  • Dai EH; The Fifth Hospital of Shijiazhuang, Hebei Medical University, Shijiazhuang, China.
  • Tian LY; The Fifth Hospital of Shijiazhuang, Hebei Medical University, Shijiazhuang, China.
  • Ma MJ; The Fifth Hospital of Shijiazhuang, Hebei Medical University, Shijiazhuang, China. daieh2008@126.com.
Signal Transduct Target Ther ; 6(1): 342, 2021 09 16.
Article en En | MEDLINE | ID: mdl-34531370
While some individuals infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) present mild-to-severe disease, many SARS-CoV-2-infected individuals are asymptomatic. We sought to identify the distinction of immune response between asymptomatic and moderate patients. We performed single-cell transcriptome and T-cell/B-cell receptor (TCR/BCR) sequencing in 37 longitudinal collected peripheral blood mononuclear cell samples from asymptomatic, moderate, and severe patients with healthy controls. Asymptomatic patients displayed increased CD56briCD16- natural killer (NK) cells and upregulation of interferon-gamma in effector CD4+ and CD8+ T cells and NK cells. They showed more robust TCR clonal expansion, especially in effector CD4+ T cells, but lack strong BCR clonal expansion compared to moderate patients. Moreover, asymptomatic patients have lower interferon-stimulated genes (ISGs) expression in general but large interpatient variability, whereas moderate patients showed various magnitude and temporal dynamics of the ISGs expression across multiple cell populations but lower than a patient with severe disease. Our data provide evidence of different immune signatures to SARS-CoV-2 in asymptomatic infections.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos / Portador Sano / Análisis de la Célula Individual / Transcriptoma / SARS-CoV-2 / COVID-19 Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Signal Transduct Target Ther Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos / Portador Sano / Análisis de la Célula Individual / Transcriptoma / SARS-CoV-2 / COVID-19 Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Signal Transduct Target Ther Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido