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Nose-to-Brain Delivery of Dexamethasone: Biodistribution Studies in Mice.
Pérez-Osorio, Iván Nicolás; Espinosa, Alejandro; Giraldo Velázquez, Manuel; Padilla, Patricia; Bárcena, Brandon; Fragoso, Gladis; Jung-Cook, Helgi; Besedovsky, Hugo; Meneses, Gabriela; Sciutto Conde, Edda Lydia.
Afiliación
  • Pérez-Osorio IN; Instituto de Investigaciones Biomédicas, (I.N.P.O, A.E., M.G.V., P.P., B.B., G.F., E.L.S.C.), Facultad de Químicas (H.J.-C.), Universidad Nacional Autónoma de México, Mexico City, Mexico; Research Group Immunophysiology, Division of Neurophysiology, Institute of Physiology and Pathophysiology, Phili
  • Espinosa A; Instituto de Investigaciones Biomédicas, (I.N.P.O, A.E., M.G.V., P.P., B.B., G.F., E.L.S.C.), Facultad de Químicas (H.J.-C.), Universidad Nacional Autónoma de México, Mexico City, Mexico; Research Group Immunophysiology, Division of Neurophysiology, Institute of Physiology and Pathophysiology, Phili
  • Giraldo Velázquez M; Instituto de Investigaciones Biomédicas, (I.N.P.O, A.E., M.G.V., P.P., B.B., G.F., E.L.S.C.), Facultad de Químicas (H.J.-C.), Universidad Nacional Autónoma de México, Mexico City, Mexico; Research Group Immunophysiology, Division of Neurophysiology, Institute of Physiology and Pathophysiology, Phili
  • Padilla P; Instituto de Investigaciones Biomédicas, (I.N.P.O, A.E., M.G.V., P.P., B.B., G.F., E.L.S.C.), Facultad de Químicas (H.J.-C.), Universidad Nacional Autónoma de México, Mexico City, Mexico; Research Group Immunophysiology, Division of Neurophysiology, Institute of Physiology and Pathophysiology, Phili
  • Bárcena B; Instituto de Investigaciones Biomédicas, (I.N.P.O, A.E., M.G.V., P.P., B.B., G.F., E.L.S.C.), Facultad de Químicas (H.J.-C.), Universidad Nacional Autónoma de México, Mexico City, Mexico; Research Group Immunophysiology, Division of Neurophysiology, Institute of Physiology and Pathophysiology, Phili
  • Fragoso G; Instituto de Investigaciones Biomédicas, (I.N.P.O, A.E., M.G.V., P.P., B.B., G.F., E.L.S.C.), Facultad de Químicas (H.J.-C.), Universidad Nacional Autónoma de México, Mexico City, Mexico; Research Group Immunophysiology, Division of Neurophysiology, Institute of Physiology and Pathophysiology, Phili
  • Jung-Cook H; Instituto de Investigaciones Biomédicas, (I.N.P.O, A.E., M.G.V., P.P., B.B., G.F., E.L.S.C.), Facultad de Químicas (H.J.-C.), Universidad Nacional Autónoma de México, Mexico City, Mexico; Research Group Immunophysiology, Division of Neurophysiology, Institute of Physiology and Pathophysiology, Phili
  • Besedovsky H; Instituto de Investigaciones Biomédicas, (I.N.P.O, A.E., M.G.V., P.P., B.B., G.F., E.L.S.C.), Facultad de Químicas (H.J.-C.), Universidad Nacional Autónoma de México, Mexico City, Mexico; Research Group Immunophysiology, Division of Neurophysiology, Institute of Physiology and Pathophysiology, Phili
  • Meneses G; Instituto de Investigaciones Biomédicas, (I.N.P.O, A.E., M.G.V., P.P., B.B., G.F., E.L.S.C.), Facultad de Químicas (H.J.-C.), Universidad Nacional Autónoma de México, Mexico City, Mexico; Research Group Immunophysiology, Division of Neurophysiology, Institute of Physiology and Pathophysiology, Phili
  • Sciutto Conde EL; Instituto de Investigaciones Biomédicas, (I.N.P.O, A.E., M.G.V., P.P., B.B., G.F., E.L.S.C.), Facultad de Químicas (H.J.-C.), Universidad Nacional Autónoma de México, Mexico City, Mexico; Research Group Immunophysiology, Division of Neurophysiology, Institute of Physiology and Pathophysiology, Phili
J Pharmacol Exp Ther ; 378(3): 244-250, 2021 09.
Article en En | MEDLINE | ID: mdl-34531307
Neuroinflammation (NI) is an important physiologic process which promotes the tissue repair and homeostatic maintenance in the central nervous system after different types of insults. However, when it is exacerbated and sustained in time, NI plays a critical role in the pathogenesis of different neurologic diseases. The high systemic doses required for brain-specific targeting lead to severe undesirable effects. The intranasal (IN) route has been proposed as an alternative drug administration route for a better NI control. Herein, the brain biodistribution of intranasally administered dexamethasone versus intravenously administered one is reported. A higher amount of dexamethasone was found in every analyzed region of those brains of intranasally administered mice. HPLC analysis also revealed that IN administration allows Dex to arrive faster and in a greater concentration to the brain in comparison with intravenous administration, data confirmed by immunofluorescence and HPLC analysis. These data support the proposal of the IN administration of Dex as an alternative for a more efficient control of NI. SIGNIFICANCE STATEMENT: This work highlights the biodistribution of dexamethasone after its intranasal administration. Intranasal administration allows for a faster arrival, better distribution, and a higher concentration of the drug within the brain compared to its intravenous administration. These results explain some of the evidence shown in a previous work in which dexamethasone controls neuroinflammation in a murine stroke model and can be used to propose alternative treatments for neuroinflammatory diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Neuroinflamatorias Límite: Animals Idioma: En Revista: J Pharmacol Exp Ther Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Neuroinflamatorias Límite: Animals Idioma: En Revista: J Pharmacol Exp Ther Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos