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Factors associated with inflamm-aging in institutionalized older people.
de Oliveira Neto, Leônidas; Tavares, Vagner Deuel de O; Agrícola, Pedro Moraes Dutra; de Oliveira, Larissa Praça; Sales, Márcia Cristina; de Sena-Evangelista, Karine Cavalcanti Maurício; Gomes, Igor Conterato; Galvão-Coelho, Nicole Leite; Pedrosa, Lúcia Fátima Campos; Lima, Kenio Costa.
Afiliación
  • de Oliveira Neto L; Department of Arts, Postgraduate Program in Rehabilitation Sciences, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 3000-Lagoa Nova, Natal, RN, 59078-970, Brazil. leonidasoliveiraneto@gmail.com.
  • Tavares VDO; Department of Physiology and Behavior, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
  • Agrícola PMD; Department of Physical Education, Maurício de Nassau College, Natal, RN, Brazil.
  • de Oliveira LP; Graduate Program in Collective Health, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
  • Sales MC; Graduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
  • de Sena-Evangelista KCM; Department of Nutrition, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
  • Gomes IC; Department of Epidemiology, School of Public Health, University of São Paulo, Brazil, São Paulo, SP, Brazil.
  • Galvão-Coelho NL; Department of Physiology and Behavior, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
  • Pedrosa LFC; Graduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
  • Lima KC; Graduate Program in Collective Health, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
Sci Rep ; 11(1): 18333, 2021 09 15.
Article en En | MEDLINE | ID: mdl-34526542
The increase in inflammatory cytokines associated with a reduction in the bioavailability of zinc has been used as a marker for inflammation. Despite the high inflammatory state found in institutionalized older individuals, few studies have proposed verifying the factors associated with this condition in this population. To verify the factors associated with inflamm-aging in institutionalized older people. A total of 178 older people (≥ 60 years old) living in nursing homes in Natal/RN were included in the study. Cluster analysis was used to identify three groups according to their inflammatory state. Analysis anthropometric, biochemical, sociodemographic, and health-related variables was carried out. In sequence, an ordinal logistic regression was performed for a confidence level of 95% in those variables with p < 0.20 in the bivariate analysis. IL-6, TNF-α, zinc, low-density lipids (LDL), high-density lipids (HDL), and triglycerides were associated with inflamm-aging. The increase of 1 unit of measurement of LDL, HDL, and triglycerides increased the chance of inflammation-aging by 1.5%, 4.1%, and 0.9%, respectively, while the oldest old (≥ 80 years old) had an 84.9% chance of presenting inflamm-aging in relation to non-long-lived older people (< 80 years). The association between biochemical markers and inflamm-aging demonstrates a relationship between endothelial injury and the inflammatory state. In addition, the presence of a greater amount of fat in the blood may present a higher relative risk of death.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Evaluación Geriátrica / Interleucina-6 / Factor de Necrosis Tumoral alfa Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do sul / Brasil Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Evaluación Geriátrica / Interleucina-6 / Factor de Necrosis Tumoral alfa Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do sul / Brasil Idioma: En Revista: Sci Rep Año: 2021 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido