Your browser doesn't support javascript.
loading
In Search of Effective UiO-66 Metal-Organic Frameworks for Artificial Kidney Application.
Dymek, Klaudia; Kurowski, Grzegorz; Kuterasinski, Lukasz; Jedrzejczyk, Roman; Szumera, Magdalena; Sitarz, Maciej; Pajdak, Anna; Kurach, Lukasz; Boguszewska-Czubara, Anna; Jodlowski, Przemyslaw J.
Afiliación
  • Dymek K; Faculty of Chemical Engineering and Technology, Cracow University of Technology, Warszawska 24, 30-155 Kraków, Poland.
  • Kurowski G; Faculty of Chemical Engineering and Technology, Cracow University of Technology, Warszawska 24, 30-155 Kraków, Poland.
  • Kuterasinski L; Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences, Niezapominajek 8, 30-239 Kraków, Poland.
  • Jedrzejczyk R; Malopolska Centre of Biotechnology, Jagiellonian University, ul. Gronostajowa 7A, 30-387 Kraków, Poland.
  • Szumera M; Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Mickiewicza 30, 30-059 Kraków, Poland.
  • Sitarz M; Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Mickiewicza 30, 30-059 Kraków, Poland.
  • Pajdak A; Strata Mechanics Research Institute, Polish Academy of Sciences, Reymonta 27, 30-059 Kraków, Poland.
  • Kurach L; Independent Laboratory of Behavioral Studies, Medical University of Lublin, 4A Chodzki Str., 20-093 Lublin, Poland.
  • Boguszewska-Czubara A; Department of Medical Chemistry, Medical University of Lublin, 4A Chodzki Str., 20-093 Lublin, Poland.
  • Jodlowski PJ; Faculty of Chemical Engineering and Technology, Cracow University of Technology, Warszawska 24, 30-155 Kraków, Poland.
ACS Appl Mater Interfaces ; 13(38): 45149-45160, 2021 Sep 29.
Article en En | MEDLINE | ID: mdl-34520182
The removal of uremic toxins from patients with acute kidney injury is a key issue in improving the quality of life for people requiring peritoneal dialysis. The currently utilized method for the removal of uremic toxins from the human organism is hemodialysis, performed on semipermeable membranes where the uremic toxins, along with small molecules, are separated from proteins and blood cells. In this study, we describe a mixed-linker modulated synthesis of zirconium-based metal-organic frameworks for efficient removal of uremic toxins. We determined that the efficient adsorption of uremic toxins is achieved by optimizing the ratio between -amino functionalization of the UiO-66 structure with 75% of -NH2 groups within organic linker structure. The maximum adsorption of hippuric acid and 3-indoloacetic acid was achieved by UiO-66-NH2 (75%) and by UiO-66-NH2 (75%) 12.5% HCl prepared by modulated synthesis. Furthermore, UiO-66-NH2 (75%) almost completely adsorbs 3-indoloacetic acid bound to bovine serum albumin, which was used as a model protein to which uremic toxins bind in the human body. The high adsorption capacity was confirmed in recyclability test, which showed almost 80% removal of 3-indoloacetic acid after the third adsorption cycle. Furthermore, in vitro cytotoxicity tests as well as hemolytic activity assay have proven that the UiO-66-based materials can be considered as potentially safe for hemodialytic purposes in living organisms.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Ftálicos / Estructuras Metalorgánicas / Tóxinas Urémicas / Hipuratos / Ácidos Indolacéticos / Riñones Artificiales Aspecto: Patient_preference Límite: Animals / Humans Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2021 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Ftálicos / Estructuras Metalorgánicas / Tóxinas Urémicas / Hipuratos / Ácidos Indolacéticos / Riñones Artificiales Aspecto: Patient_preference Límite: Animals / Humans Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2021 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Estados Unidos