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Risk factors associated with the mortality rate of oral squamous cell carcinoma patients: A 10-year retrospective study.
Ahmad, Paras; Nawaz, Rubbia; Qurban, Maria; Shaikh, Gul Muhammad; Mohamed, Roshan Noor; Nagarajappa, Anil Kumar; Asif, Jawaad Ahmed; Alam, Mohammad Khursheed.
Afiliación
  • Ahmad P; Oral Medicine Unit, School of Dental Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.
  • Nawaz R; Private Dental Practice, Attock, Punjab, Pakistan.
  • Qurban M; Private Dental Practice, Okara, Punjab, Pakistan.
  • Shaikh GM; Department of Dental Education and Research, Shahida Islam Medical and Dental College, Lodhran, Punjab, Pakistan.
  • Mohamed RN; Department of Pediatric Dentistry, Faculty of Dentistry, Taif University, Taif, Saudi Arabia.
  • Nagarajappa AK; Department of Oral and Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jouf University, Sakaka, Saudi Arabia.
  • Asif JA; Department of Oral and Maxillofacial Department, School of Dental Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia.
  • Alam MK; Department of Orthodontics, College of Dentistry, Jouf University, Sakaka, Saudi Arabia.
Medicine (Baltimore) ; 100(36): e27127, 2021 Sep 10.
Article en En | MEDLINE | ID: mdl-34516504
ABSTRACT: In Malaysia, oral cancer is very common and the reported 5-year survival of such patients is nearly 50% after treatment with surgery and radiotherapy, much lower than most of the developed countries. This study aimed to investigate the socio-demographic and clinicopathological parameters that influence the mortality rate of the patients suffering from oral squamous cell carcinoma (OSCC) in the Kelantanse population.In this retrospective study, data regarding socio-demographic, clinicopathological factors, and treatment outcome associated with OSCC were gathered from the archives of the medical records office of Hospital Universiti Sains Malaysia. For statistical analysis, simple and multiple logistic regression were performed. The significance level was set to P < .25.A total of 211 OSCC cases were registered in Hospital Universiti Sains Malaysia from January 1, 2000 to December 31, 2018. Majority of them were male (57.82%), non-smoker (54.97%), non-alcohol consumer (91.94%), and non-betel quid chewer (93.83%) Malay (60.66%) patients. The tongue was the most commonly involved part of the oral cavity (41.52%). Histologically, the majority of the cases had moderately-differentiated OSCC (52.82%). Most of the patients were diagnosed at stage IV at the time of diagnosis (61.61%). When this study was performed, the survival status of the majority of the patients was alive (68.24%).Within the analyzed socio-demographic and clinicopathological parameters, gender, alcohol consumption, T-classification, histological grading, and treatment status have been demonstrated as an independent risk factors for mortality rate in multivariate analysis. Hence, these parameters need to be taken into account for the individualized therapy management of OSCC patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Boca / Carcinoma de Células Escamosas Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Medicine (Baltimore) Año: 2021 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Boca / Carcinoma de Células Escamosas Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Medicine (Baltimore) Año: 2021 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Estados Unidos