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Predictive factors of non-treatment and non-persistence to osteoporosis medication after fragility hip fractures at 3 years after discharge: a multicentre, prospective cohort study in the northern Kyushu district of Japan.
Kanahori, Masaya; Matsumoto, Yoshihiro; Fujiwara, Toshifumi; Kimura, Atsushi; Tsutsui, Tomoko; Arisumi, Shinkichi; Oyamada, Akiko; Ohishi, Masanobu; Ikuta, Ko; Tsuchiya, Kuniyoshi; Tayama, Naohisa; Tomari, Shinji; Miyahara, Hisaaki; Mae, Takao; Hara, Toshihiko; Saito, Taichi; Arizono, Takeshi; Kaji, Kozo; Mawatari, Taro; Fujiwara, Masami; Takasaki, Minoru; Shin, Kunichika; Ninomiya, Kenichi; Nakaie, Kazutoshi; Antoku, Yasuaki; Iwamoto, Yukihide; Nakashima, Yasuharu.
Afiliación
  • Kanahori M; Department of Orthopaedic Surgery, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
  • Matsumoto Y; Department of Orthopaedic Surgery, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan. ymatsu@ortho.med.kyushu-u.ac.jp.
  • Fujiwara T; Department of Orthopaedic Surgery, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
  • Kimura A; Department of Orthopaedic Surgery, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
  • Tsutsui T; Department of Orthopaedic Surgery, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
  • Arisumi S; Department of Orthopaedic Surgery, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
  • Oyamada A; Department of Orthopaedic Surgery, Saga Handicapped Children's Hospital, Saga, Japan.
  • Ohishi M; Department of Orthopaedic Surgery, Chihaya Hospital, Fukuoka, Japan.
  • Ikuta K; Department of Orthopaedic Surgery, Karatsu Red Cross Hospital, Saga, Japan.
  • Tsuchiya K; Department of Orthopaedic Surgery, Japan Community Healthcare Organization, Kyushu Hospital, Fukuoka, Japan.
  • Tayama N; Department of Orthopaedic Surgery, Steel Memorial Yawata Hospital, Fukuoka, Japan.
  • Tomari S; Department of Orthopaedic Surgery, Japanese Red Cross Fukuoka Hospital, Fukuoka, Japan.
  • Miyahara H; Department of Orthopaedic Surgery, National Hospital Organization Kyushu Medical Centre, Fukuoka, Japan.
  • Mae T; Department of Orthopaedic Surgery, Saga-Ken Medical Centre Koseikan, Saga, Japan.
  • Hara T; Department of Orthopaedic Surgery, Aso Iizuka Hospital, Fukuoka, Japan.
  • Saito T; Department of Orthopaedic Surgery, Fukuoka City Hospital, Fukuoka, Japan.
  • Arizono T; Department of Orthopaedic Surgery, Kyushu Central Hospital of the Mutual Aid Association of Public School Teachers, Fukuoka, Japan.
  • Kaji K; Department of Orthopaedic Surgery, Kyushu Rosai Hospital, Fukuoka, Japan.
  • Mawatari T; Department of Orthopaedic Surgery, Hamanomachi Hospital, Fukuoka, Japan.
  • Fujiwara M; Department of Orthopaedic Surgery, Sada Hospital, Fukuoka, Japan.
  • Takasaki M; Department of Orthopaedic Surgery, Harasanshin Hospital, Fukuoka, Japan.
  • Shin K; Department of Orthopaedic Surgery, Saiseikai Yahata General Hospital, Fukuoka, Japan.
  • Ninomiya K; Department of Orthopaedic Surgery, Koga Hospital 21, Fukuoka, Japan.
  • Nakaie K; Department of Orthopaedic Surgery, National Hospital Organization Fukuoka-Higashi Medical Centre, Fukuoka, Japan.
  • Antoku Y; Faculty of Medicine, Hospital Informatic Centre, Oita University, Oita, Japan.
  • Iwamoto Y; Department of Orthopaedic Surgery, Kyushu Rosai Hospital, Fukuoka, Japan.
  • Nakashima Y; Department of Orthopaedic Surgery, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
Arch Osteoporos ; 16(1): 132, 2021 09 13.
Article en En | MEDLINE | ID: mdl-34515859
We examined osteoporosis medication use and factors affecting persistence in 497 patients with fragility hip fractures. Only 25.5% of patients received continuous medication for 3 years, and 44.1% of patients received no treatment. Low Barthel index at discharge was a risk factor for both non-treatment and non-persistence to osteoporosis medication. PURPOSE: Fragility hip fractures (FHF) caused by osteoporosis decrease the quality of life and worsen life expectancy. Use of osteoporosis medication may be an efficient method in the prevention of secondary FHF. However, previous studies have reported low rates of osteoporosis medication and persistence after FHF. This study aimed to evaluate osteoporosis medication use and factors affecting persistence in patients with FHF in the northern Kyushu area of Japan. METHODS: A total of 497 FHF patients aged ≥ 60 years with a 3-year follow-up were included. We prospectively collected data from questionnaires sent every 6 months regarding compliance with osteoporosis medication. We compared baseline characteristics among three groups: no treatment (NT), no persistence (NP), and persistence (P), and conducted multivariable regression models to determine covariates associated with non-treatment (NT vs. NP/P) and non-persistence (NP vs. P). RESULTS: There were 219 (44.1%), 151 (30.4%), and 127 (25.5%) patients in the NT, NP, and P groups, respectively. Factors associated with non-treatment were male sex, chronic kidney disease, no previous osteoporosis treatment, and low Barthel index (BI) at discharge. The only factor associated with non-persistence was a low BI at discharge. Factors associated with a low BI at discharge were male sex, older age, trochanteric fracture, and surgical delay. CONCLUSION: Low BI at discharge is a risk factor for both non-treatment and non-persistence to osteoporosis medication. Therefore, appropriate interventions to improve BI may result in persistence to osteoporosis medication.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoporosis / Conservadores de la Densidad Ósea / Fracturas Osteoporóticas / Fracturas de Cadera Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Aged / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Arch Osteoporos Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteoporosis / Conservadores de la Densidad Ósea / Fracturas Osteoporóticas / Fracturas de Cadera Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Aged / Humans / Male País/Región como asunto: Asia Idioma: En Revista: Arch Osteoporos Año: 2021 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido