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Escherichia coli and Colorectal Cancer: Unfolding the Enigmatic Relationship.
Nouri, Roghayeh; Hasani, Alka; Shirazi, Kourosh Masnadi; Alivand, Mohammad Reza; Sepehri, Bita; Sotoodeh, Simin; Hemmati, Fatemeh; Rezaee, Mohammad Ahangarzadeh.
Afiliación
  • Nouri R; Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Hasani A; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Shirazi KM; Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Alivand MR; Department of Medical Microbiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Sepehri B; Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Sotoodeh S; Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Hemmati F; Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Rezaee MA; Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Curr Pharm Biotechnol ; 23(10): 1257-1268, 2022.
Article en En | MEDLINE | ID: mdl-34514986
Colorectal cancer (CRC) is one of the deadliest cancers in the world. Specific strains of intestinal Escherichia coli (E. coli) may influence the initiation and development of CRC by exploiting virulence factors and inflammatory pathways. Mucosa-associated E. coli strains are more prevalent in CRC biopsies in comparison to healthy controls. Moreover, these strains can survive and replicate within macrophages and induce a pro-inflammatory response. Chronic exposure to inflammatory mediators can lead to increased cell proliferation and cancer. Production of colobactin toxin by the majority of mucosa-associated E. coli isolated from CRC patients is another notable finding. Colibactin-producing E. coli strains, in particular, induce double-strand DNA breaks, stop the cell cycle, involve in chromosomal rearrangements of mammalian cells and are implicated in carcinogenic effects in animal models. Moreover, some enteropathogenic E. coli (EPEC) strains are able to survive and replicate in colon cells as chronic intracellular pathogens and may promote susceptibility to CRC by downregulation of DNA Mismatch Repair (MMR) proteins. In this review, we discuss current evidence and focus on the mechanisms by which E. coli can influence the development of CRC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Infecciones por Escherichia coli Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Curr Pharm Biotechnol Asunto de la revista: BIOTECNOLOGIA / FARMACOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Infecciones por Escherichia coli Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Curr Pharm Biotechnol Asunto de la revista: BIOTECNOLOGIA / FARMACOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Países Bajos