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HIV Viremia Is Associated With APOL1 Variants and Reduced JC-Viruria.
Kruzel-Davila, Etty; Sankofi, Barbara Mensah; Kubi Amos-Abanyie, Ernestine; Ghansah, Anita; Nyarko, Alexander; Agyemang, Seth; Awandare, Gordon A; Szwarcwort-Cohen, Moran; Reiner-Benaim, Anat; Hijazi, Basem; Ulasi, Ifeoma; Raji, Yemi Raheem; Boima, Vincent; Osafo, Charlotte; May Adabayeri, Victoria; Matekole, Michael; Olanrewaju, Timothy O; Ajayi, Samuel; Mamven, Manmak; Antwi, Sampson; Ademola, Adebowale D; Plange-Rhule, Jacob; Arogundade, Fatiu; Akyaw, Priscilla Abena; Winkler, Cheryl A; Salako, Babatunde L; Ojo, Akinlolu; Skorecki, Karl; Adu, Dwomoa.
Afiliación
  • Kruzel-Davila E; Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel.
  • Sankofi BM; Nephrology Department, Rambam Health Care Campus, Haifa, Israel.
  • Kubi Amos-Abanyie E; College of Health Sciences, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
  • Ghansah A; West African Centre for Cell Biology of Infectious Pathogens, College of Basic and Applied Sciences, University of Ghana, Accra, Ghana.
  • Nyarko A; College of Health Sciences, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
  • Agyemang S; College of Health Sciences, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
  • Awandare GA; College of Health Sciences, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
  • Szwarcwort-Cohen M; West African Centre for Cell Biology of Infectious Pathogens, College of Basic and Applied Sciences, University of Ghana, Accra, Ghana.
  • Reiner-Benaim A; University of Ghana Medical School, College of Health Sciences, University of Ghana, Accra, Ghana.
  • Hijazi B; West African Centre for Cell Biology of Infectious Pathogens, College of Basic and Applied Sciences, University of Ghana, Accra, Ghana.
  • Ulasi I; Rambam Health Care Campus, Haifa, Israel.
  • Raji YR; Rambam Health Care Campus, Haifa, Israel.
  • Boima V; Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
  • Osafo C; Department of Medicine, College of Health Sciences University of Nigeria, Enugu, Nigeria.
  • May Adabayeri V; Department of Medicine, University of Ibadan, Ibadan, Nigeria.
  • Matekole M; University of Ghana Medical School, College of Health Sciences, University of Ghana, Accra, Ghana.
  • Olanrewaju TO; University of Ghana Medical School, College of Health Sciences, University of Ghana, Accra, Ghana.
  • Ajayi S; University of Ghana Medical School, College of Health Sciences, University of Ghana, Accra, Ghana.
  • Mamven M; University of Ghana Medical School, College of Health Sciences, University of Ghana, Accra, Ghana.
  • Antwi S; Department of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
  • Ademola AD; Department of Medicine, University of Ibadan, Ibadan, Nigeria.
  • Plange-Rhule J; Department of Medicine, University of Abuja, Abuja, Nigeria.
  • Arogundade F; Department of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
  • Akyaw PA; Department of Medicine, University of Ibadan, Ibadan, Nigeria.
  • Winkler CA; Department of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
  • Salako BL; Obafemi Awolowo University, Ile-Ife, Nigeria.
  • Ojo A; College of Health Sciences, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
  • Skorecki K; Department of Medicine, Frederick National Laboratory for Cancer Research (NIH), Frederick, MD, United States.
  • Adu D; Department of Medicine, University of Ibadan, Ibadan, Nigeria.
Front Med (Lausanne) ; 8: 718300, 2021.
Article en En | MEDLINE | ID: mdl-34513880
Variants in the Apolipoprotein L1 (APOL1) gene (G1-rs60910145, rs73885319, G2-rs71785313) are common in Africans and in individuals of recent African ancestry and are associated with an increased risk of non-diabetic chronic kidney disease (CKD) and in particular of HIV associated nephropathy (HIVAN). In light of the significantly increased risk of HIVAN in carriers of two APOL1 risk alleles, a role in HIV infectivity has been postulated in the mechanism of APOL1 associated kidney disease. Herein, we aim to explore the association between HIV viremia and APOL1 genotype. In addition, we investigated interaction between BK and JC viruria, CKD and HIV viremia. A total of 199 persons living with HIV/AIDS (comprising 82 CKD cases and 117 controls) from among the participants in the ongoing Human Heredity and Health in Africa (H3Africa) Kidney Disease Research Network case control study have been recruited. The two APOL1 renal risk alleles (RRA) genotypes were associated with a higher risk of CKD (OR 12.6, 95% CI 3.89-40.8, p < 0.0001). Even a single APOL1 RRA was associated with CKD risk (OR 4.42, 95% CI 1.49-13.15, p = 0.007). The 2 APOL1 RRA genotypes were associated with an increased probability of having HIV viremia (OR 2.37 95% CI 1.0-5.63, p = 0.05). HIV viremia was associated with increased CKD risk (OR 7.45, 95% CI 1.66-33.35, P = 0.009) and with a significant reduction of JC virus urine shedding (OR 0.35, 95% CI 0.12-0.98, p = 0.046). In contrast to prior studies, JC viruria was not associated with CKD but was restricted in patients with HIV viremia, regardless of CKD status. These findings suggest a role of APOL1 variants in HIV infectivity and emphasize that JC viruria can serve as biomarker for innate immune system activation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Risk_factors_studies Idioma: En Revista: Front Med (Lausanne) Año: 2021 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Risk_factors_studies Idioma: En Revista: Front Med (Lausanne) Año: 2021 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Suiza