Your browser doesn't support javascript.
loading
A finite element model of the cardiac ventricles with coupled circulation: Biventricular mesh generation with hexahedral elements, airbags and a functional mockup interface to the circulation.
Zhang, Yue; Adams, Jennifer; Wang, Vicky Y; Horwitz, Lucas; Tartibi, Mehrzad; Morgan, Ashley E; Kim, Jiwon; Wallace, Arthur W; Weinsaft, Jonathan W; Ge, Liang; Ratcliffe, Mark B.
Afiliación
  • Zhang Y; Department of Surgery, University of California, San Francisco, CA, USA; Department of Bioengineering, University of California, San Francisco, CA, USA; San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
  • Adams J; School of Medicine, University of Texas Rio Grande Valley, Edinburg, TX, USA.
  • Wang VY; Department of Surgery, University of California, San Francisco, CA, USA; Department of Bioengineering, University of California, San Francisco, CA, USA; San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
  • Horwitz L; San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
  • Tartibi M; Delbeat Inc. Berkeley, CA, USA.
  • Morgan AE; Department of Surgery, University of Utah, Salt Lake City, UT, USA.
  • Kim J; Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Wallace AW; Department of Anesthesia, University of California, San Francisco, CA, USA; San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
  • Weinsaft JW; Department of Medicine, Weill Cornell Medicine, New York, NY, USA.
  • Ge L; Department of Surgery, University of California, San Francisco, CA, USA; Department of Bioengineering, University of California, San Francisco, CA, USA; San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA.
  • Ratcliffe MB; Department of Surgery, University of California, San Francisco, CA, USA; Department of Bioengineering, University of California, San Francisco, CA, USA; San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA. Electronic address: mark.ratcliffe@va.gov.
Comput Biol Med ; 137: 104840, 2021 10.
Article en En | MEDLINE | ID: mdl-34508972
INTRODUCTION: Finite element (FE) mechanics models of the heart are becoming more sophisticated. However, there is lack of consensus about optimal element type and coupling of FE models to the circulation. We describe biventricular (left (LV) and right (RV) ventricles) FE mechanics model creation using hexahedral elements, airbags and a functional mockup interface (FMI) to lumped-parameter models of the circulation. METHODS: Cardiac MRI (CMR) was performed in two healthy volunteers and a single patient with ischemic heart disease (IHD). CMR images were segmented and surfaced, meshing with hexahedral elements was performed with a "thin butterfly with septum" topology. LV and RV inflow and outflow airbags were coupled to lumped-parameter circulation models with an FMI interface. Pulmonary constriction (PAC) and vena cava occlusion (VCO) were simulated and end-systolic pressure-volume relations (ESPVR) were calculated. RESULTS: Mesh construction was prompt with representative contouring and mesh adjustment requiring 32 and 26 min Respectively. The numbers of elements ranged from 4104 to 5184 with a representative Jacobian of 1.0026 ± 0.4531. Agreement between CMR-based surfaces and mesh was excellent with root-mean-squared error of 0.589 ± 0.321 mm. The LV ESPVR slope was 3.37 ± 0.09 in volunteers but 2.74 in the IHD patient. The effect of PAC and VCO on LV ESPVR was consistent with ventricular interaction (p = 0.0286). CONCLUSION: Successful co-simulation using a biventricular FE mechanics model with hexahedral elements, airbags and an FMI interface to lumped-parameter model of the circulation was demonstrated. Future studies will include comparison of element type and study of cardiovascular pathologies and device therapies.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Airbags / Ventrículos Cardíacos Límite: Humans Idioma: En Revista: Comput Biol Med Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Airbags / Ventrículos Cardíacos Límite: Humans Idioma: En Revista: Comput Biol Med Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos