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Fortifying a meal with oyster mushroom powder beneficially affects postprandial glucagon-like peptide-1, non-esterified free fatty acids and hunger sensation in adults with impaired glucose tolerance: a double-blind randomized controlled crossover trial.
Dicks, Lisa; Jakobs, Linda; Sari, Miriam; Hambitzer, Reinhard; Ludwig, Norbert; Simon, Marie-Christine; Stehle, Peter; Stoffel-Wagner, Birgit; Helfrich, Hans-Peter; Ahlborn, Jenny; Rühl, Martin; Hartmann, Bolette; Holst, Jens J; Ellinger, Sabine.
Afiliación
  • Dicks L; Department of Nutrition and Food Sciences, Niederrhein University of Applied Sciences, Mönchengladbach, Germany.
  • Jakobs L; Department of Nutrition and Food Sciences, Human Nutrition, University of Bonn, Meckenheimer Allee 166a, 53115, Bonn, Germany.
  • Sari M; Department of Nutrition and Food Sciences, Niederrhein University of Applied Sciences, Mönchengladbach, Germany.
  • Hambitzer R; Department of Nutrition and Food Sciences, Nutrition and Microbiota, University of Bonn, Bonn, Germany.
  • Ludwig N; Department of Nutrition and Food Sciences, Niederrhein University of Applied Sciences, Mönchengladbach, Germany.
  • Simon MC; Department of Nutrition and Food Sciences, Niederrhein University of Applied Sciences, Mönchengladbach, Germany.
  • Stehle P; Department of Nutrition and Food Sciences, Niederrhein University of Applied Sciences, Mönchengladbach, Germany.
  • Stoffel-Wagner B; Department of Nutrition and Food Sciences, Nutrition and Microbiota, University of Bonn, Bonn, Germany.
  • Helfrich HP; Department of Nutrition and Food Sciences, Nutritional Physiology, University of Bonn, Bonn, Germany.
  • Ahlborn J; Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany.
  • Rühl M; Institute of Numerical Simulation, University of Bonn, Bonn, Germany.
  • Hartmann B; Institute of Food Chemistry and Food Biotechnology, University of Giessen, Giessen, Germany.
  • Holst JJ; Institute of Food Chemistry and Food Biotechnology, University of Giessen, Giessen, Germany.
  • Ellinger S; NNF Center for Basic Metabolic Research and Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Eur J Nutr ; 61(2): 687-701, 2022 Mar.
Article en En | MEDLINE | ID: mdl-34505919
PURPOSE: Impaired glucose tolerance (IGT) is a pathophysiological condition characterized by insulin resistance with known metabolic consequences such as postprandial hyperglycemia and hypertriglyceridemia. We hypothesized that fortifying a meal with mushrooms rich in ß-glucans may diminish glucose and triglyceride responses by improving postprandial gastrointestinal hormone release. METHODS: In a randomized controlled crossover study, 22 subjects with IGT ingested a meal either enriched with 20 g powder (8.1 g ß-glucans) of oven-dried Pleurotus ostreatus (enriched meal, EN) or without enrichment (control meal, CON). Blood was collected before and repeatedly within 4 h after the meal to determine AUC of glucose (primary outcome), insulin, triglycerides, non-esterified free fatty acids (NEFAs), glucagon-like peptide-1 (GLP-1), gastric inhibitory polypeptide (GIP) and ghrelin. Appetite sensations (hunger, satiety, fullness, and desire to eat) were assessed before and after meal consumption by visual analog scales. RESULTS: Postprandial glucose, insulin, triglycerides, GIP and ghrelin concentrations as well as the corresponding AUCs did not differ between EN and CON. NEFAs-AUC was 14% lower (P = 0.026) and GLP-1-AUC 17% higher (P = 0.001) after EN compared to CON. Appetite ratings did not differ between treatments, except for hunger (AUC 22% lower after EN vs. CON; P = 0.031). CONCLUSION: The observed immediate postprandial metabolic changes indicate that an easily manageable fortification of a single meal with powder from dried oyster mushrooms as ß-glucan source may improve postprandial metabolism. If the effect is preserved long term, this measure can diminish the risk for further development of overweight/obesity and type 2 diabetes in subjects with IGT. CLINICAL TRIAL REGISTRATION: German Clinical Trial Register on 09/08/2018; trial-ID: DRKS00015244.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Intolerancia a la Glucosa / Pleurotus / Diabetes Mellitus Tipo 2 Tipo de estudio: Clinical_trials Aspecto: Determinantes_sociais_saude Límite: Adult / Humans Idioma: En Revista: Eur J Nutr Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2022 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Intolerancia a la Glucosa / Pleurotus / Diabetes Mellitus Tipo 2 Tipo de estudio: Clinical_trials Aspecto: Determinantes_sociais_saude Límite: Adult / Humans Idioma: En Revista: Eur J Nutr Asunto de la revista: CIENCIAS DA NUTRICAO Año: 2022 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Alemania