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Comparison between the Antioxidant and Antidiabetic Activity of Fenugreek and Buckthorn in Streptozotocin-Induced Diabetic Male Rats.
Alsieni, Mohammed A; El Rabey, Haddad A; Al-Sieni, Abdulbasit I; Al-Seeni, Madeha N.
Afiliación
  • Alsieni MA; Pharmacology Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
  • El Rabey HA; Biochemistry Department, Faculty of Science, University of Tabuk, Tabuk, Saudi Arabia.
  • Al-Sieni AI; Bioinformatics Department, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, P.O. Box 79, Sadat City, Egypt.
  • Al-Seeni MN; Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Biomed Res Int ; 2021: 7202447, 2021.
Article en En | MEDLINE | ID: mdl-34497854
This study is aimed at comparing the antidiabetic and antioxidant potential of fenugreek and buckthorn which are commonly used in modulating diabetes in the Middle East. In this study, the antioxidant and antidiabetic activity of the aqueous extracts of the leaf and seed of fenugreek and buckthorn was tested in streptozotocin-induced diabetic male rats fed with a fat-rich diet for 8 weeks. Thirty-six male albino rats were divided into 6 groups (n = 6); the 1st group was the negative control. Diabetes was induced in the other 30 rats using streptozotocin, which were then divided into 5 groups; the 2nd was the untreated positive diabetic group, the 3rd was treated with fenugreek leaf aqueous extract, the 4th was treated with the fenugreek seed aqueous extract, the 5th was treated with buckthorn leaf aqueous extract, and the 6th was treated with buckthorn seed aqueous extract. The positive control group showed an increase in blood sugar, glycated hemoglobin, liver function enzymes, lactate dehydrogenase, kidney indices, total cholesterol, triglycerides, low- and very-low-density lipoprotein, immunoglobulins, and lipid peroxidation and a decrease in high-density lipoprotein, albumin, and antioxidant activity. The histology of the liver and testes showed severe histopathological alterations. Rats of groups 4-6 that were treated with the aqueous extract of the leaf and seed extract of fenugreek and buckthorn showed improvement of all biochemical and histopathological parameters. The seed extract of fenugreek and buckthorn showed more antioxidant activity than their leaves.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Rhamnus / Trigonella / Diabetes Mellitus Experimental / Hipoglucemiantes / Antioxidantes Límite: Animals Idioma: En Revista: Biomed Res Int Año: 2021 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Estados Unidos
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Extractos Vegetales / Rhamnus / Trigonella / Diabetes Mellitus Experimental / Hipoglucemiantes / Antioxidantes Límite: Animals Idioma: En Revista: Biomed Res Int Año: 2021 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Estados Unidos