The Combined Treatment With the FLT3-Inhibitor AC220 and the Complex I Inhibitor IACS-010759 Synergistically Depletes Wt- and FLT3-Mutated Acute Myeloid Leukemia Cells.

Lu, Xiyuan; Han, Lina; Busquets, Jonathan; Collins, Meghan; Lodi, Alessia; Marszalek, Joseph R; Konopleva, Marina; Tiziani, Stefano

Lu, Xiyuan; Han, Lina; Busquets, Jonathan; Collins, Meghan; Lodi, Alessia; Marszalek, Joseph R; Konopleva, Marina; Tiziani, Stefano.

Afiliación

Lu X; Department of Nutritional Sciences, The University of Texas at Austin, Austin, TX, United States.
Han L; Department of Pediatrics, Dell Medical School, The University of Texas at Austin, Austin, TX, United States.
Busquets J; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Collins M; Department of Nutritional Sciences, The University of Texas at Austin, Austin, TX, United States.
Lodi A; Department of Pediatrics, Dell Medical School, The University of Texas at Austin, Austin, TX, United States.
Marszalek JR; Department of Nutritional Sciences, The University of Texas at Austin, Austin, TX, United States.
Konopleva M; Department of Pediatrics, Dell Medical School, The University of Texas at Austin, Austin, TX, United States.
Tiziani S; Department of Nutritional Sciences, The University of Texas at Austin, Austin, TX, United States.

Front Oncol ; 11: 686765, 2021.

Article en En | MEDLINE | ID: mdl-34490088

Palabras clave

FLT3-inhibitor; acute myeloid leukemia; complex I inhibitor; high-throughput screening; metabolomics

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Oncol Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza

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