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Human host genetics and susceptibility to ZIKV infection.
Ferraris, Pauline; Wichit, Sineewanlaya; Cordel, Nadège; Missé, Dorothée.
Afiliación
  • Ferraris P; MIVEGEC, Univ. Montpellier, IRD, CNRS, 34394 Montpellier, France. Electronic address: pauline.ferraris@gmail.com.
  • Wichit S; Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Nakhon Pathom 73170, Thailand.
  • Cordel N; Guadeloupe University Hospital, Department of Dermatology and Clinical Immunology, Pointe-à-Pitre, Guadeloupe and Normandie University, UNIROUEN, IRIB, Inserm, U1234, Rouen, France.
  • Missé D; MIVEGEC, Univ. Montpellier, IRD, CNRS, 34394 Montpellier, France.
Infect Genet Evol ; 95: 105066, 2021 11.
Article en En | MEDLINE | ID: mdl-34487865
Managing emerging infectious diseases is a current challenge in the fields of microbiology and epidemiology. Indeed, among other environmental and human-related factors, climate change and global warming favor the emergence of new pathogens. The recent Zika virus (ZIKV) epidemic, of which the large and rapid spread surprised the scientific community, is a reminder of the importance to study viruses currently responsible for sporadic infections. Increasing our knowledge of key factors involved in emerging infections is essential to implement specific monitoring that can be oriented according to the pathogen, targeted population, or at-risk environment. Recent technological developments, such as high-throughput sequencing, genome-wide association studies and CRISPR screenings have allowed the identification of human single nucleotide polymorphisms (SNPs) involved in infectious disease outcome. This review focuses on the human genetic host factors that have been identified and shown to be associated with the pathogenesis of ZIKV infection and candidate SNP targets.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Transmisibles Emergentes / Virus Zika / Infección por el Virus Zika Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Infect Genet Evol Asunto de la revista: BIOLOGIA / DOENCAS TRANSMISSIVEIS / GENETICA Año: 2021 Tipo del documento: Article Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Transmisibles Emergentes / Virus Zika / Infección por el Virus Zika Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Infect Genet Evol Asunto de la revista: BIOLOGIA / DOENCAS TRANSMISSIVEIS / GENETICA Año: 2021 Tipo del documento: Article Pais de publicación: Países Bajos