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Human α-defensin 5 suppressed colon cancer growth by targeting PI3K pathway.
Qiao, Qiao; Bai, Ruixia; Song, Wanying; Gao, Haining; Zhang, Minyu; Lu, Jingkun; Hong, Mei; Zhang, Xuan; Sun, Peng; Zhang, Qian; Zhao, Pengwei.
Afiliación
  • Qiao Q; Department of Obstetrics and Gynecology, Affiliated Hospital of Inner Mongolia Medical University, No.1, Tongdao North Street, Huimin District, Hohhot, 010050, PR China. Electronic address: qiaoqiao771011@126.com.
  • Bai R; Department of Clinical Laboratory, Inner Mongolia People's Hospital, Zhaowuda Road, Hohhot, 010018, PR China. Electronic address: yxybrx@126.com.
  • Song W; Laboratory of Microbiology and Immunology, School of Basic Medical Science, Inner Mongolia Medical University, Xinhua Street, Hohhot, 010059, PR China. Electronic address: swy7990@126.com.
  • Gao H; Laboratory of Microbiology and Immunology, School of Basic Medical Science, Inner Mongolia Medical University, Xinhua Street, Hohhot, 010059, PR China. Electronic address: 1766768147@qq.com.
  • Zhang M; Laboratory of Microbiology and Immunology, School of Basic Medical Science, Inner Mongolia Medical University, Xinhua Street, Hohhot, 010059, PR China. Electronic address: 49271886@qq.com.
  • Lu J; Laboratory of Microbiology and Immunology, School of Basic Medical Science, Inner Mongolia Medical University, Xinhua Street, Hohhot, 010059, PR China. Electronic address: 360569392@qq.com.
  • Hong M; Laboratory of Microbiology and Immunology, School of Basic Medical Science, Inner Mongolia Medical University, Xinhua Street, Hohhot, 010059, PR China. Electronic address: hongmei060@126.com.
  • Zhang X; Laboratory of Microbiology and Immunology, School of Basic Medical Science, Inner Mongolia Medical University, Xinhua Street, Hohhot, 010059, PR China. Electronic address: zhxuan024@163.com.
  • Sun P; Laboratory of Microbiology and Immunology, School of Basic Medical Science, Inner Mongolia Medical University, Xinhua Street, Hohhot, 010059, PR China. Electronic address: 1318329288@qq.com.
  • Zhang Q; Pediatric Intensive Care Unit, Affiliated Hospital of Inner Mongolia Medical University, 1#, Xinhua Street, Hohhot, 010050, PR China. Electronic address: 980848134@qq.com.
  • Zhao P; Laboratory of Microbiology and Immunology, School of Basic Medical Science, Inner Mongolia Medical University, Xinhua Street, Hohhot, 010059, PR China. Electronic address: pengwzhao@126.com.
Exp Cell Res ; 407(2): 112809, 2021 10 15.
Article en En | MEDLINE | ID: mdl-34487729
Defensins are highly conserved antimicrobial peptides, which ubiquitously expressed in different species. In addition to the functions in host defense, their aberrant expression have also been documented in cancerous tissue including breast cancer, lung caner and renal carcinoma etc. Whereas, roles of Defensin Alpha 5 (DEFA5) in colon cancer has not been explored. Bioinformatic analysis was used to study the expression of DEFA5 and its correlation with clinical outcomes; Western blot, qPCR, Co-immunoprecipitation, xenograft models were used to the study the molecular mechanism. Decreased expression of DEFA5 at protein level was observed in colon tissues. Colon cancer cell lines proliferation and colony formation capacity were significantly suppressed by DEFA5 overexpression. Moreover, in vivo tumor growth in nude mice was also suppressed by DEFA5 overexpression, suggesting a tumor suppressor role of DEFA5 in colon cancer. Mechanistically, DEFA5 directly binds to the subunits of PI3K complex, thus attenuates the downstream signaling transduction, leads to delayed cell growth and metastasis. Collectively, we concluded that DEFA5 showed an inhibitory effect in colon cancer cell growth and may serve as a potential tumor suppressor in colon cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Regulación Neoplásica de la Expresión Génica / Neoplasias del Colon / Fosfatidilinositol 3-Quinasas / Alfa-Defensinas Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Exp Cell Res Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Regulación Neoplásica de la Expresión Génica / Neoplasias del Colon / Fosfatidilinositol 3-Quinasas / Alfa-Defensinas Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: Exp Cell Res Año: 2021 Tipo del documento: Article Pais de publicación: Estados Unidos