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The prognostic power of inflammatory indices and clinical factors in metastatic castration-resistant prostate cancer patients treated with radium-223 (BIO-Ra study).
Bauckneht, Matteo; Rebuzzi, Sara Elena; Signori, Alessio; Frantellizzi, Viviana; Murianni, Veronica; Lodi Rizzini, Elisa; Mascia, Manlio; Lavelli, Valentina; Donegani, Maria Isabella; Ponzano, Marta; Gaudiano, Angela; Stazza, Maria Lina; Licari, Maria; Cavallini, Letizia; Laghi, Viola; Cindolo, Luca; Maggi, Martina; Sciarra, Alessandro; Mammucci, Paolo; Sambuceti, Gianmario; Costa, Renato Patrizio; Spanu, Angela; Rubini, Giuseppe; Monari, Fabio; De Vincentis, Giuseppe; Fornarini, Giuseppe.
Afiliación
  • Bauckneht M; Nuclear Medicine, IRCCS Ospedale Policlinico San Martino, Genova, Italy. matteo.bauckneht@hsanmartino.it.
  • Rebuzzi SE; Department of Health Sciences (DISSAL), University of Genova, Genova, Italy. matteo.bauckneht@hsanmartino.it.
  • Signori A; Medical Oncology Unit 1, IRCCS Ospedale Policlinico San Martino, Genova, Italy.
  • Frantellizzi V; Department of Internal Medicine and Medical Specialties, University of Genova, Genova, Italy.
  • Murianni V; Department of Health Sciences (DISSAL), University of Genova, Genova, Italy.
  • Lodi Rizzini E; Department of Radiological Sciences, Oncology and Anatomical Pathology, Sapienza University of Rome, Rome, Italy.
  • Mascia M; Medical Oncology Unit 1, IRCCS Ospedale Policlinico San Martino, Genova, Italy.
  • Lavelli V; Department of Internal Medicine and Medical Specialties, University of Genova, Genova, Italy.
  • Donegani MI; Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.
  • Ponzano M; Unit of Nuclear Medicine, Spirito Santo Hospital, Pescara, Italy.
  • Gaudiano A; Nuclear Medicine Section, Interdisciplinary Department of Medicine, University of Bari "Aldo Moro", Bari, Italy.
  • Stazza ML; Nuclear Medicine, IRCCS Ospedale Policlinico San Martino, Genova, Italy.
  • Licari M; Department of Health Sciences (DISSAL), University of Genova, Genova, Italy.
  • Cavallini L; Department of Health Sciences (DISSAL), University of Genova, Genova, Italy.
  • Laghi V; Nuclear Medicine Section, Interdisciplinary Department of Medicine, University of Bari "Aldo Moro", Bari, Italy.
  • Cindolo L; Unit of Nuclear Medicine, Department of Medical, Surgical and Experimental Sciences, University of Sassari, Sassari, Italy.
  • Maggi M; Unit of Nuclear Medicine, Biomedical Department of Internal and Specialist Medicine, University of Palermo, Palermo, Italy.
  • Sciarra A; Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.
  • Mammucci P; Department of Experimental Diagnostic and Specialty Medicine, Alma Mater Studiorum Bologna University, Bologna, Italy.
  • Sambuceti G; Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, Bologna, Italy.
  • Costa RP; Department of Experimental Diagnostic and Specialty Medicine, Alma Mater Studiorum Bologna University, Bologna, Italy.
  • Spanu A; Department of Urology, Villa Stuart Private Hospital, Rome, Italy.
  • Rubini G; Department of Urology, Sapienza University of Rome, Policlinico Umberto I, Rome, Italy.
  • Monari F; Department of Urology, Sapienza University of Rome, Policlinico Umberto I, Rome, Italy.
  • De Vincentis G; Nuclear Medicine Section, Interdisciplinary Department of Medicine, University of Bari "Aldo Moro", Bari, Italy.
  • Fornarini G; Nuclear Medicine, IRCCS Ospedale Policlinico San Martino, Genova, Italy.
Eur J Nucl Med Mol Imaging ; 49(3): 1063-1074, 2022 02.
Article en En | MEDLINE | ID: mdl-34486070
PURPOSE: To combine peripheral blood indices and clinical factors in a prognostic score for metastatic castration-resistant prostate cancer (mCRPC) patients treated with radium-223 dichloride ([223Ra]RaCl2). PATIENTS AND METHODS: Baseline neutrophil-to-lymphocyte ratio (NLR), derived NLR (donor), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), systemic inflammation index (SII), Eastern Cooperative Oncology Group performance status (ECOG PS), Gleason score (GS) group, number of bone metastases, prostate-specific antigen (PSA), alkaline phosphatase (ALP), line of therapy, previous chemotherapy, and the presence of lymphadenopathies were collected from seven Italian centers between 2013 and 2020. Lab and clinical data were assessed in correlation with the overall survival (OS). Inflammatory indices were then included separately in the multivariable analyses with the prognostic clinical factors. The model with the highest discriminative ability (c-index) was chosen to develop the BIO-Ra score. RESULTS: Five hundred and nineteen mCRPC patients (median OS: 19.9 months) were enrolled. Higher NLR, dNLR, PLR, and SII and lower LMR predicted worse OS (all with a p < 0.001). The multivariable model including NLR, ECOG PS, number of bone metastases, ALP, and PSA (c-index: 0.724) was chosen to develop the BIO-Ra score. Using the Schneeweiss scoring system, the BIO-Ra score identified three prognostic groups (36%, 27.3%, and 36.6% patients, respectively) with distinct median OS (31, 26.6, and 9.6 months, respectively; hazard ratio: 1.62, p = 0.008 for group 2 vs. 1 and 5.77, p < 0.001 for group 3 vs. 1). CONCLUSIONS: The BIO-Ra score represents an easy and widely applicable tool for the prognostic stratification of mCRPC patients treated with [223Ra]RaCl2 with no additional costs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Radio (Elemento) / Neoplasias de la Próstata Resistentes a la Castración Tipo de estudio: Observational_studies / Prognostic_studies Límite: Humans / Male Idioma: En Revista: Eur J Nucl Med Mol Imaging Asunto de la revista: MEDICINA NUCLEAR Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Radio (Elemento) / Neoplasias de la Próstata Resistentes a la Castración Tipo de estudio: Observational_studies / Prognostic_studies Límite: Humans / Male Idioma: En Revista: Eur J Nucl Med Mol Imaging Asunto de la revista: MEDICINA NUCLEAR Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania