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Old pesticide, new use: Smart and safe enantiomer of isocarbophos in locust control.
Kong, Yuan; Ji, Chenyang; Qu, Jianli; Chen, Yuanchen; Wu, Shenggan; Zhu, Xinkai; Niu, Lixi; Zhao, Meirong.
Afiliación
  • Kong Y; Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou 310014, China.
  • Ji C; Interdisciplinary Research Academy, Zhejiang Shuren University, Hangzhou 310015, China.
  • Qu J; Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou 310014, China.
  • Chen Y; Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou 310014, China.
  • Wu S; Institute of Agro-product Safety and Nutrition, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China.
  • Zhu X; Institute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering under the National Ministry of Education, Shanxi University, Taiyuan 030006, China.
  • Niu L; Institute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering under the National Ministry of Education, Shanxi University, Taiyuan 030006, China. Electronic address: nlx@sxu.edu.cn.
  • Zhao M; Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province, College of Environment, Zhejiang University of Technology, Hangzhou 310014, China. Electronic address: zhaomr@zjut.edu.cn.
Ecotoxicol Environ Saf ; 225: 112710, 2021 Dec 01.
Article en En | MEDLINE | ID: mdl-34481357
Locust plagues are still worldwide problems. Selecting active enantiomers from current chiral insecticides is necessary for controlling locusts and mitigating the pesticide pollution in agricultural lands. Herein, two enantiomers of isocarbophos (ICP) were separated and the enantioselectivity in insecticidal activity against the pest Locusta migratoria manilensis (L. migratoria) and mechanisms were investigated. The significant difference of LD50 between (+)-ICP (0.609 mg/kg bw) and (-)-ICP (79.412 mg/kg bw) demonstrated that (+)-ICP was a more effective enantiomer. The enantioselectivity in insecticidal activity of ICP enantiomers could be attributed to the selective affinity to acetylcholinesterase (AChE). Results of in vivo and in vitro assays suggested that AChE was more sensitive to (+)-ICP. In addition, molecular docking showed that the -CDOKER energies of (+)-ICP and (-)-ICP were 25.6652 and 24.4169, respectively, which suggested a stronger affinity between (+)-ICP and AChE. Significant selectivity also occurred in detoxifying enzymes activities (carboxylesterases (CarEs) and glutathione S-transferases (GSTs)) and related gene expressions. Suppression of detoxifying enzymes activities with (+)-ICP treatment suggested that (-)-ICP may induce the detoxifying enzyme-mediated ICP resistance. A more comprehensive understanding of the enantioselectivity of ICP is necessary for improving regulation and risk assessment of ICP.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plaguicidas / Locusta migratoria Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Ecotoxicol Environ Saf Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plaguicidas / Locusta migratoria Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Ecotoxicol Environ Saf Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos