Your browser doesn't support javascript.
loading
Venetoclax-based combinations in AML and high-risk MDS prior to and following allogeneic hematopoietic cell transplant.
Bewersdorf, Jan Philipp; Derkach, Andriy; Gowda, Lohith; Menghrajani, Kamal; DeWolf, Susan; Ruiz, Josel D; Ponce, Doris M; Shaffer, Brian C; Tamari, Roni; Young, James W; Jakubowski, Ann A; Gyurkocza, Boglarka; Chan, Alexander; Xiao, Wenbin; Glass, Jacob; King, Amber C; Cai, Sheng F; Daniyan, Anthony; Famulare, Christopher; Cuello, Bernadette M; Podoltsev, Nikolai A; Roshal, Mikhail; Giralt, Sergio; Perales, Miguel-Angel; Seropian, Stuart; Cho, Christina; Zeidan, Amer M; Prebet, Thomas; Stein, Eytan M; Tallman, Martin S; Goldberg, Aaron D; Stahl, Maximilian.
Afiliación
  • Bewersdorf JP; Section of Hematology, Department of Internal Medicine, Yale University School of Medicine, Yale University, New Haven, CT, USA.
  • Derkach A; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Gowda L; Section of Hematology, Department of Internal Medicine, Yale University School of Medicine, Yale University, New Haven, CT, USA.
  • Menghrajani K; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
  • DeWolf S; Weill Cornell Medical College, New York, NY, USA.
  • Ruiz JD; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Ponce DM; Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Shaffer BC; Weill Cornell Medical College, New York, NY, USA.
  • Tamari R; Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Young JW; Weill Cornell Medical College, New York, NY, USA.
  • Jakubowski AA; Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Gyurkocza B; Weill Cornell Medical College, New York, NY, USA.
  • Chan A; Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Xiao W; Weill Cornell Medical College, New York, NY, USA.
  • Glass J; Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • King AC; The Rockefeller University, New York, NY, USA.
  • Cai SF; Weill Cornell Medical College, New York, NY, USA.
  • Daniyan A; Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Famulare C; Weill Cornell Medical College, New York, NY, USA.
  • Cuello BM; Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Podoltsev NA; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Roshal M; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Giralt S; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Perales MA; Weill Cornell Medical College, New York, NY, USA.
  • Seropian S; Department of Pharmacy, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • Cho C; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Zeidan AM; Weill Cornell Medical College, New York, NY, USA.
  • Prebet T; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Stein EM; Weill Cornell Medical College, New York, NY, USA.
  • Tallman MS; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Goldberg AD; Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
  • Stahl M; Section of Hematology, Department of Internal Medicine, Yale University School of Medicine, Yale University, New Haven, CT, USA.
Leuk Lymphoma ; 62(14): 3394-3401, 2021 12.
Article en En | MEDLINE | ID: mdl-34477024
The role of allogeneic hematopoietic cell transplant (allo-HCT) as consolidation after initial venetoclax therapy and the efficacy of venetoclax salvage therapy for relapse after allo-HCT in patients with acute myeloid leukemia (AML) are unclear. We conducted a retrospective study of patients with AML or myelodysplastic syndrome (MDS) who received venetoclax either before or after allo-HCT at Memorial Sloan Kettering Cancer Center and Yale University from 11 August 2016 to 16 November 2020. Among 39 heavily pretreated patients who received venetoclax before allo-HCT, median OS from allo-HCT was not reached after a median follow up of 12.5 months resulting in a 12-month OS estimate of 79.0%. In 37 patients who had received venetoclax-based combinations as salvage therapy after allo-HCT, the overall response rate was 32% with a median OS of 4.7 months (12-month OS estimate: 43.4%). Four patients underwent a second allo-HCT following venetoclax-based salvage therapy suggesting it as a potential salvage treatment option.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Trasplante de Células Madre Hematopoyéticas Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Leuk Lymphoma Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia Mieloide Aguda / Trasplante de Células Madre Hematopoyéticas Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Leuk Lymphoma Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos