Amino acid composition of uremic middle and low molecular weight retention products.
Adv Exp Med Biol
; 223: 197-204, 1987.
Article
en En
| MEDLINE
| ID: mdl-3447436
In order to characterize the spectrum of small peptides retained in chronic renal failure, we carried out high pressure liquid chromatography (HPLC) of serum ultrafiltrates from patients with chronic renal failure (CRF), acute renal failure (ARF), and normal subjects. HPLC patterns in CRF resolved into more than twenty peaks; those in ARF contained fewer peaks and resembled that of normals. We carried out amino acid analysis of HPLC fractions after hydrolysis with 6N HC1 of four patients with CRF, one patient with ARF, and one normal subject. Following hydrolysis each HPLC fraction yielded several amino acids. Glycine, leucine, serine, phosphoserine, glutamic acid, and phenylalanine were found in greatest frequency in the four CRF patients.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Péptidos
/
Toxinas Biológicas
/
Uremia
Límite:
Humans
Idioma:
En
Revista:
Adv Exp Med Biol
Año:
1987
Tipo del documento:
Article
Pais de publicación:
Estados Unidos