ACC, Adrenocortical carcinoma; BBB, brain blood barrier; BLCA, Bladder Urothelial Carcinoma; BRCA, Breast invasive carcinoma; CDF, cumulative distribution function; CESC, Cervical squamous cell carcinoma and endocervical adenocarcinoma; CGGA, Chinese Glioma Genome Atlas; CHOL, Cholangiocarcinoma; CNA, copy number alternations; CNV, copy number variation; COAD, Colon adenocarcinoma; CSF-1, colony-stimulating factor-1; DLBC, Lymphoid Neoplasm Diffuse Large B-cell Lymphoma; DMP, differentially methylated position; ESCA, Esophageal carcinoma; GBM, glioblastoma; GEO, Gene Expression Omnibus; GO, gene ontology; GSEA, gene set enrichment analysis; GSVA, gene set variation analysis; Glioma microenvironment; HNSC, Head and Neck squamous cell carcinoma; IGR, intergenic region; IHC, immunohistochemistry; IL, interleukin; Immunotherapy; KEGG, Kyoto Encyclopaedia of Genes and Genomes; KICH, Kidney Chromophobe; KIRC, Kidney renal clear cell carcinoma; KIRP, Kidney renal papillary cell carcinoma; LGG, low grade glioma; LIHC, Liver hepatocellular carcinoma; LUAD, Lung adenocarcinoma; LUSC, Lung squamous cell carcinoma; MMP-2, matrix metalloproteinase-2; MT1, MMP membrane type 1 matrix metalloprotease; Machine learning; Macrophage; OV, Ovarian serous cystadenocarcinoma; PAAD, Pancreatic adenocarcinoma; PAM, partition around medoids; PCA, principal component analysis; PCPG, Pheochromocytoma and Paraganglioma; PRAD, Prostate adenocarcinoma; Prognostic model; READ, Rectum adenocarcinoma; SARC, Sarcoma; SKCM, Skin Cutaneous Melanoma; SNP, single-nucleotide polymorphism; SNV, single-nucleotide variant; STAD, Stomach adenocarcinoma; SVM, Support Vector Machines; TAM, tumor associated macrophage; TCGA, The Cancer Genome Atlas; TGF-ß, tumor growth factor-ß; THCA, Thyroid carcinoma; THYM, Thymoma; TIMP-2, tissue inhibitor of metalloproteinase-2; TLR2, toll-like receptor 2; TME, tumor microenvironment; TNFα, tumor necrosis factor α; TSS, transcription start site; UCEC, Uterine Corpus Endometrial Carcinoma; UCS, Uterine Carcinosarcoma; WGCNA, weighted gene co-expression network analysis; pamr, prediction analysis for microarrays