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Pharmacogenetic polymorphisms affecting bisoprolol response.
Castaño-Amores, Celia; Díaz-Villamarín, Xando; Pérez-Gutiérrez, Ana María; Antúnez-Rodríguez, Alba; Pozo-Agundo, Ana; Moreno-Escobar, Eduardo; Sánchez-Ramos, Jesús Gabriel; Martínez-González, Luis Javier; Dávila-Fajardo, Cristina Lucía.
Afiliación
  • Castaño-Amores C; Pharmacy Unit; Hospital Universitario clínico San Cecilio - Instituto de investigación biosanitaria (ibs.Granada), Granada, Spain.
  • Díaz-Villamarín X; Pharmacy Unit; Hospital Universitario clínico San Cecilio - Instituto de investigación biosanitaria (ibs.Granada), Granada, Spain; Genomics Unit; Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research (GENyO), Granada, Spain. Electronic address: xdiaz@ibsgranada
  • Pérez-Gutiérrez AM; Department of Biochemistry and Molecular Biology II; School of Pharmacy, University of Granada, Granada, Spain.
  • Antúnez-Rodríguez A; Genomics Unit; Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research (GENyO), Granada, Spain.
  • Pozo-Agundo A; Genomics Unit; Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research (GENyO), Granada, Spain.
  • Moreno-Escobar E; Cardiology Unit; Hospital Universitario clínico San Cecilio - Instituto de investigación biosanitaria (ibs.Granada), Granada, Spain.
  • Sánchez-Ramos JG; Cardiology Unit; Hospital Universitario clínico San Cecilio - Instituto de investigación biosanitaria (ibs.Granada), Granada, Spain.
  • Martínez-González LJ; Genomics Unit; Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research (GENyO), Granada, Spain.
  • Dávila-Fajardo CL; Pharmacy Unit; Hospital Universitario Virgen de las Nieves - Instituto de investigación biosanitaria (ibs.Granada), Granada, Spain.
Biomed Pharmacother ; 142: 112069, 2021 Oct.
Article en En | MEDLINE | ID: mdl-34470728
ß-blockers are commonly prescribed to treat multiple cardiovascular (CV) diseases, but, frequently, adverse drug reactions and intolerance limit their use in clinical practice. Interindividual variability in response to ß-blockers may be explained by genetic differences. In fact, pharmacogenetic interactions for some of these drugs have been widely studied, such as metoprolol. But studies that explore genetic variants affecting bisoprolol response are inconclusive, limited or confusing because of mixed results with other ß-Blockers, different genetic polymorphisms observed, endpoint studied etc. Because of this, we performed a systematic review in order to find relevant genetic variants affecting bisoprolol response. We have found genetic polymorphism in several genes, but most of the studies focused in ADRB variants. The ADRB1 Arg389Gly (rs1801253) was the most studied genetic polymorphism and it seems to influence the response to bisoprolol, although studies are inconclusive. Even, we performed a meta-analysis about its influence on systolic/diastolic blood pressure in patients treated with bisoprolol, but this did not show statistically significant results. In conclusion, many genetic polymorphisms have been assessed about their influence on patients´ response to bisoprolol and the ADRB1 Arg389Gly (rs1801253) seems the most relevant genetic polymorphism in this regard but results have not been confirmed with a meta-analysis. Our results support the need of further studies about the impact of genetic variants on bisoprolol response, considering different genetic polymorphisms and conducting single and multiple SNPs analysis, including other clinical parameters related to bisoprolol response in a multivariate study.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Farmacogenética / Bisoprolol / Antagonistas de Receptores Adrenérgicos beta 1 Tipo de estudio: Systematic_reviews Límite: Humans Idioma: En Revista: Biomed Pharmacother Año: 2021 Tipo del documento: Article País de afiliación: España Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Farmacogenética / Bisoprolol / Antagonistas de Receptores Adrenérgicos beta 1 Tipo de estudio: Systematic_reviews Límite: Humans Idioma: En Revista: Biomed Pharmacother Año: 2021 Tipo del documento: Article País de afiliación: España Pais de publicación: Francia