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Utility of Fine-Needle Aspirations to Diagnose Pediatric Thyroid Nodules.
Jia, Margaret R; Baran, Julia A; Bauer, Andrew J; Isaza, Amber; Surrey, Lea F; Bhatti, Tricia; McGrath, Cindy; Jalaly, Jalal; Mostoufi-Moab, Sogol; Adzick, N Scott; Kazahaya, Ken; Sisko, Lindsay; Franco, Aime T; Escobar, Fernando A; Krishnamurthy, Ganesh; Patel, Tasleema; Baloch, Zubair.
Afiliación
  • Jia MR; College of Medicine, The Ohio State University, Columbus, Ohio, USA.
  • Baran JA; Division of Endocrinology and Diabetes, The Thyroid Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Bauer AJ; Division of Endocrinology and Diabetes, The Thyroid Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA, bauera@chop.edu.
  • Isaza A; Division of Endocrinology and Diabetes, The Thyroid Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Surrey LF; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Bhatti T; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • McGrath C; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Jalaly J; Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Mostoufi-Moab S; Division of Endocrinology and Diabetes, The Thyroid Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Adzick NS; Division of Pediatric Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Kazahaya K; Department of Surgery, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Sisko L; Department of Otorhinolaryngology-Head and Neck Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Franco AT; Division of Pediatric Otolaryngology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Escobar FA; Division of Endocrinology and Diabetes, The Thyroid Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Krishnamurthy G; Division of Endocrinology and Diabetes, The Thyroid Center, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Patel T; Division of Interventional Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Baloch Z; Division of Interventional Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Horm Res Paediatr ; 94(7-8): 263-274, 2021.
Article en En | MEDLINE | ID: mdl-34469888
INTRODUCTION: Risk of malignancy for pediatric thyroid nodules classified according to The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) is not well defined. Correlations between risk of malignancy and ancillary clinical data remain inconclusive. We report a single institutional experience of fine-needle aspiration (FNA) to improve upon current management paradigm of thyroid nodules. METHODS: A retrospective chart review of 575 thyroid nodules was performed of 324 patients who underwent 340 FNAs between 2008 and 2018 at the Children's Hospital of Philadelphia. Demographics, ultrasound (US) characteristics, FNA cytology, surgical pathology, and ancillary data were reviewed. RESULTS: The rate of malignancy according to TBSRTC was 0.0% for category I, 0.8% for category II, 15.6% for category III, 54.5% for category IV, 100.0% for category V, and 100.0% for category VI. The cumulative Thyroid Imaging Reporting and Data System (TI-RADS) score was significantly correlated with benign and malignant nodules on pathology (p < 2.2e-16). Distribution of TI-RADS for cytologically indeterminate nodules with benign or malignant pathology revealed significant differences for composition (p = 3.20e-8) and echogenic foci (p = 0.005) but not for echogenicity (p = 0.445), shape (p = 0.160), margins (p = 0.220), and size (p = 0.105). Distributions of thyroid-stimulating hormone levels between benign and malignant patients was significant (p = 1.58e-3). CONCLUSIONS: Nodules with TI-RADS scores >3 should undergo FNA, irrespective of size; surgical resection is recommended for nodules classified as TBSRTC category IV and V due to high risk of malignancy. US surveillance instead of FNA can be performed for nodules with TI-RADS scores ≤3.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nódulo Tiroideo / Biopsia con Aguja Fina Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Child / Humans Idioma: En Revista: Horm Res Paediatr Asunto de la revista: ENDOCRINOLOGIA / PEDIATRIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nódulo Tiroideo / Biopsia con Aguja Fina Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Child / Humans Idioma: En Revista: Horm Res Paediatr Asunto de la revista: ENDOCRINOLOGIA / PEDIATRIA Año: 2021 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza