Your browser doesn't support javascript.
loading
Over-expression of SRD5A3 and its prognostic significance in breast cancer.
Zhang, Yong-Ping; Na, Wen-Ting; Dai, Xiao-Qiang; Li, Ruo-Fei; Wang, Jian-Xiong; Gao, Ting; Zhang, Wei-Bo; Xiang, Cheng.
Afiliación
  • Zhang YP; Department of Vascular and Thyroid Surgery, Xianyang Central Hospital, Xianyang, 712000, Shanxi, China.
  • Na WT; Department of Anesthesiology, Xi'an Yanliang Railway Hospital, Xi'an, 710089, Shanxi, China.
  • Dai XQ; Department of Vascular and Thyroid Surgery, Xianyang Central Hospital, Xianyang, 712000, Shanxi, China.
  • Li RF; Department of Orthopaedics, Xianyang Central Hospital, Xianyang, 712000, Shanxi, China.
  • Wang JX; Department of Vascular and Thyroid Surgery, Xianyang Central Hospital, Xianyang, 712000, Shanxi, China.
  • Gao T; Department of Pulmonary and Critical Care Medicine, Xianyang Central Hospital, Xianyang, 712000, Shanxi, China.
  • Zhang WB; Department of Pathology, Xianyang Central Hospital, Xianyang, 712000, Shanxi, China.
  • Xiang C; Department of Thyroid Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009, Zhejiang, China. chengxiang@zju.edu.cn.
World J Surg Oncol ; 19(1): 260, 2021 Aug 31.
Article en En | MEDLINE | ID: mdl-34465365
OBJECTIVE: The study aimed to compare the Steroid 5 alpha-reductase 3 (SRD5A3) expression levels in breast cancer (BC) and normal tissues, to investigate the prognostic value of SRD5A3 mRNA expression in BC patients and to identify the SRD5A3-related signaling pathways using bioinformatics approaches. METHODS: We evaluated the expression levels of SRD5A3 and survival data in BC patients using different bioinformatic databases. Further, Cox regression analysis was conducted to predict the independent prognostic factors for BC. Moreover, the association of SRD5A3 with clinicopathological factors was measured through LinkedOmics database. And the potential role of SRD5A3 was determined by Gene Ontology and KEGG pathway enrichment analysis. Finally, protein network of SRD5A3 was constructed and genetic alterations were analyzed. RESULTS: Bioinformatic data indicated that both mRNA and protein expression levels of SRD5A3 were higher in BC group than those in the normal group (P < 0.05). Besides, BC patients with higher SRD5A3 mRNA expression levels had a lower overall survival (all P < 0.05). Cox regression analysis further demonstrated the independent prognostic value of SRD5A3 in BC (P = 0.015). SRD5A3 mRNA expression was significantly associated with N stage (P < 0.001), age (P < 0.05), and histologic subtype (P < 0.001) but had no significant relationship with other clinical characteristics (all P > 0.05). Moreover, the functional enrichment analysis revealed that the SRD5A3 was involved in metabolism-related pathways (all P < 0.05). CONCLUSIONS: SRD5A3 was highly expressed in BC tissues and high SRD5A3 expression was related to poorer prognosis. SRD5A3 serves as an oncogene and might function as a potential biomarker for prognosis and a therapeutic target for BC.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: World J Surg Oncol Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama Tipo de estudio: Prognostic_studies Límite: Female / Humans Idioma: En Revista: World J Surg Oncol Año: 2021 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido